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首页> 外文期刊>Dermatology: international journal for clinical and investigative dermatology >Two distinct types of speckled lentiginous nevi characterized by macular versus papular speckles.
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Two distinct types of speckled lentiginous nevi characterized by macular versus papular speckles.

机译：两种不同类型的斑点状点状痣，以黄斑斑块样或丘疹样斑点为特征。

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BACKGROUND: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. OBJECTIVE: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. METHODS: A review of case reports on SLN published during the years 1970-2004 was performed. RESULTS: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a 'jentigo' pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. CONCLUSIONS: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level.
机译：背景：斑点状的痣状痣（SLN;同义词：痣）是一种暗点状的浅褐色斑点，通常以尺寸有限的孤立病灶出现，但有时可能累及身体的大部分区域。迄今为止，该皮肤病已被认为代表一种临床实体。目的：由于前哨淋巴结有时与复杂的出生缺陷有关，例如色素性血管性眼病，色素性角化病或SLN综合征，因此我们测试了我们的想法，即可能存在两种不同类型的SLN，每一种都与一种特定的综合征有关。方法：对1970-2004年间发表的关于SLN的病例报告进行了回顾。结果：对病例的评估提供了证据，表明存在两种不同类型的SLN，分别是黄斑型还是丘疹型SLN，每种都与一种特定的综合征有关。黄斑SLN的特征是棕褐色的背景，带有较深的扁平斑点。斑点的分布相当均匀，类似于圆点图案。在组织病理学上，这种SLN的特征是在较暗的斑点中称为“ jentigo”模式，在乳头顶端的真皮表皮交界处有一些黑素细胞巢，而背景色素沉着则显示了lentigo的微观特征。 。丘疹性SLN的特征是浅褐色的斑丘疹，以丘疹或结节的形式由多个黑素细胞痣叠加，显示出不均匀的分布，让人联想到星图。可能会出现小的黑色斑点。在组织病理学上，丘疹成分由真皮或复合性黑素细胞痣组成。两种类型的SLN的分离很重要，因为我们的分析表明黄斑性SLN是特定类型的色素性血管炎的标志，而丘疹性SLN通常存在于色素性角化病和SLN综合征中。结论：黄斑SLN和丘疹SLN似乎是两个不同的皮肤实体。当在分子水平分析这种痣时，这种二分法可能变得很重要。

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