...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Development >Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities.
【24h】

Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities.

机译：维甲酸信号诱导Nolz1，并通过独特的阻遏物活性控制运动神经元亚型的同一性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The acquisition and maintenance of final neuronal identity depends in part upon the implementation of fate-specification programs in postmitotic neurons; however, the mechanisms involved remain unclear. In the developing spinal cord, retinoic acid (RA) signaling pathways specify the columnar and divisional identities of postmitotic motoneurons (MNs). Here we show that RA signals induce expression of the NET transcriptional regulator Nolz1 in differentiated chick MNs, where it regulates the progressive specification of prospective Lim3-negative motor columns. Nolz1 controls the initial formation of forelimb and thoracic Lim3-negative motor columns by downregulating Lim3 expression and maintaining the expression of key homeodomain proteins necessary for MN identity and survival. At forelimb levels, Nolz1 specifies lateral motor column (LMC) identity by inducing the expression of the postmitotic LMC determinant Hoxc6, and implements the partial specification of lateral LMC identity through Lim1 induction.The specificity of Nolz1 function depends upon distinct repressor activities that require, in part, the modulatory activity of Grg5, an atypical member of the Gro-TLE family of co-repressors. Thus, RA signals regulate diverse events in MN subtype specification by inducing the expression of a key transcriptional regulator that controls multiple developmental pathways via functionally distinct repressor complexes.
机译：最终神经元身份的获取和维持部分取决于有丝分裂后神经元中命运指定程序的实施;但是，所涉及的机制仍不清楚。在发育中的脊髓中，视黄酸（RA）信号通路指定了有丝分裂后运动神经元（MNs）的柱状和分区身份。在这里，我们显示RA信号诱导分化的雏鸟MN中NET转录调节因子Nolz1的表达，在其中它调节前瞻性Lim3阴性运动柱的进行性规范。 Nolz1通过下调Lim3表达并维持MN身份和生存所必需的关键同源域蛋白的表达，来控制前肢和胸部Lim3阴性运动柱的初始形成。在前肢水平，Nolz1通过诱导有丝分裂后LMC决定簇Hoxc6的表达来指定横向运动柱（LMC）身份，并通过Lim1诱导来实现侧向LMC身份的部分说明.Nolz1功能的特异性取决于不同的阻遏物活性，部分是Grg5（Gro-TLE家族共抑制子家族的非典型成员）的调节活性。因此，RA信号通过诱导关键的转录调节子的表达来调节MN亚型规范中的各种事件，所述转录子通过功能上不同的阻遏物复合物控制多个发育途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号