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首页> 外文期刊>Development >Evidence for a dynamic spatiotemporal fate map and early fate restrictions of premigratory avian neural crest.
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Evidence for a dynamic spatiotemporal fate map and early fate restrictions of premigratory avian neural crest.

机译：动态时空命运图和迁徙前禽神经c的早期命运限制的证据。

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Colonization of trunk neural crest derivatives in avians follows a ventral to dorsal order beginning with sympathetic ganglia, Schwann cells, sensory ganglia and finally melanocytes. Continuous crest emigration underlies this process, which is accounted for by a progressive ventral to dorsal relocation of neural tube progenitors prior to departure. This causes a gradual narrowing of FoxD3, Sox9 and Snail2 expression domains in the dorsal tube that characterize the neural progenitors of the crest and these genes are no longer transcribed by the time melanoblasts begin emigrating. Consistently, the final localization of crest cells can be predicted from their relative ventrodorsal position within the premigratory domain or by their time of delamination. Thus, a dynamic spatiotemporal fate map of crest derivatives exists in the dorsal tube at flank levels of the axis with its midline region acting as a sink for the ordered ingression and departure of progenitors. Furthermore, discrete lineage analysis of the dorsal midline at progressive stages generated progeny in single rather than multiple derivatives, revealing early fate restrictions. Compatible with this notion, when early emigrating ;neural' progenitors were diverted into the lateral ;melanocytic' pathway, they still adopted neural traits, suggesting that initial fate acquisition is independent of the migratory environment and that the potential of crest cells prior to emigration is limited.
机译：鸟类在躯干神经neural衍生物中的定殖遵循腹侧至背侧顺序，始于交感神经节，许旺细胞，感觉神经节，最后是黑素细胞。持续的波峰移民是这一过程的基础，这是由于在离开之前神经管祖细胞从腹侧到背侧逐渐重定位所致。这会导致背管中FoxD3，Sox9和Snail2表达域的逐渐缩小，这是ize神经祖细胞的特征，而在黑素细胞开始移出时，这些基因不再被转录。一致地，rest细胞的最终定位可以从它们在迁移前区域内的相对腹侧位置或通过它们的分层时间来预测。因此，在轴的侧面水平处，背管中存在波峰导数的动态时空命运图，其中线区域充当祖细胞有序进入和离开的汇点。此外，进行中的背中线的离散谱系分析在单个而不是多个衍生物中产生后代，揭示了早期的命运限制。与此观点相符，当早期移居;神经的祖细胞转移到侧向;黑素细胞的途径时，他们仍然采用神经性状，这表明最初的命运获取与迁徙环境无关，而移居之前的c细胞潜力是有限。

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