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首页> 外文期刊>Development >BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions.
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BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions.

机译：BMP I型受体复合物具有介导细胞命运和轴突指导决策的独特活性。

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The finding that morphogens, signalling molecules that specify cell identity, also act as axon guidance molecules has raised the possibility that the mechanisms that establish neural cell fate are also used to assemble neuronal circuits. It remains unresolved, however, how cells differentially transduce the cell fate specification and guidance activities of morphogens. To address this question, we have examined the mechanism by which the Bone morphogenetic proteins (BMPs) guide commissural axons in the developing spinal cord. In contrast to studies that have suggested that morphogens direct axon guidance decisions using non-canonical signal transduction factors, our results indicate that canonical components of the BMP signalling pathway, the type I BMP receptors (BMPRs), are both necessary and sufficient to specify the fate of commissural neurons and guide their axonal projections. However, whereas the induction of cell fate is a shared property of both type I BMPRs, axon guidance is chiefly mediated by only one of the type I BMPRs, BMPRIB. Taken together, these results indicate that the diverse activities of BMP morphogens can be accounted for by the differential use of distinct components of the canonical BMPR complex.
机译：形态发生子，即表明细胞身份的信号分子，也可作为轴突指导分子的发现，增加了建立神经细胞命运的机制也可用于组装神经元回路的可能性。然而，细胞如何差异化地转导细胞形态特征和指导细胞形态发生仍未解决。为了解决这个问题，我们研究了骨形态发生蛋白（BMP）引导发育中的脊髓的连合轴突的机制。与研究表明形态发生素使用非经典信号转导因子指导轴突指导决策的研究相反，我们的结果表明，BMP信号传导途径的经典组成部分，即I型BMP受体（BMPR），既是必要的也是足以确定特定的连合神经元的命运，并指导其轴突投射。然而，虽然细胞命运的诱导是两种I型BMPR的共有特性，但是轴突引导主要仅由一种I型BMPR介导，BMPRIB。两者合计，这些结果表明BMP形态发生子的各种活动可以通过规范BMPR复杂的不同成分的不同用法来解释。

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