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首页> 外文期刊>Development >MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
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MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.

机译：MAB-10 / NAB与LIN-29 / EGR共同作用，以调节线虫的终末分化和从幼虫到成虫的过渡。

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In Caenorhabditis elegans, a well-defined pathway of heterochronic genes ensures the proper timing of stage-specific developmental events. During the final larval stage, an upregulation of the let-7 microRNA indirectly activates the terminal differentiation factor and central regulator of the larval-to-adult transition, LIN-29, via the downregulation of the let-7 target genes lin-41 and hbl-1. Here, we identify a new heterochronic gene, mab-10, and show that mab-10 encodes a NAB (NGFI-A-binding protein) transcriptional co-factor. MAB-10 acts with LIN-29 to control the expression of genes required to regulate a subset of differentiation events during the larval-to-adult transition, and we show that the NAB-interaction domain of LIN-29 is conserved in Kruppel-family EGR (early growth response) proteins. In mammals, EGR proteins control the differentiation of multiple cell lineages, and EGR-1 acts with NAB proteins to initiate menarche by regulating the transcription of the luteinizing hormone beta subunit. Genome-wide association studies of humans and various studies of mouse recently have implicated the mammalian homologs of the C. elegans heterochronic gene lin-28 in regulating cellular differentiation and the timing of menarche. Our work suggests that human homologs of multiple C. elegans heterochronic genes might act in an evolutionarily conserved pathway to promote cellular differentiation and the onset of puberty.
机译：在秀丽隐杆线虫中，明确定义的异时基因途径可确保阶段特异性发育事件的适当时机。在最后的幼虫阶段，let-7微小RNA的上调通过let-7靶基因lin-41和lin-41的下调间接激活了幼虫-成年过渡LIN-29的终末分化因子和中央调节因子。 hbl-1。在这里，我们确定了一个新的异时基因mab-10，并显示mab-10编码NAB（NGFI-A结合蛋白）转录辅因子。 MAB-10与LIN-29共同作用，以控制调节幼虫到成人过渡过程中分化事件子集所需的基因的表达，并且我们证明LIN-29的NAB相互作用域在Kruppel家族中是保守的EGR（早期生长反应）蛋白。在哺乳动物中，EGR蛋白控制多种细胞谱系的分化，而EGR-1与NAB蛋白共同作用，通过调节促黄体生成激素β亚基的转录来启动月经初潮。人类的全基因组关联研究和小鼠的各种研究最近暗示线虫异时基因lin-28的哺乳动物同源物在调节细胞分化和初潮的时间中起作用。我们的工作表明，多个秀丽隐杆线虫异时基因的人类同源物可能在进化上保守的途径中起作用，以促进细胞分化和青春期的发作。

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