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首页> 外文期刊>Development >Regulated tissue fluidity steers zebrafish body elongation
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Regulated tissue fluidity steers zebrafish body elongation

机译：调节的组织流动性引导斑马鱼的身体伸长

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摘要

The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of motile progenitors of the axial skeleton, musculature and spinal cord. We measure the 3D cell flow field of the zebrafish tailbud and identify changes in tissue fluidity revealed by reductions in the coherence of cell motion without alteration of cell velocities. We find a directed posterior flow wherein the polarization between individual cell motion is high, reflecting ordered collective migration. At the posterior tip of the tailbud, this flow makes sharp bilateral turns facilitated by extensive cell mixing due to increased directional variability of individual cell motions. Inhibition of Wnt or Fgf signaling or cadherin 2 function reduces the coherence of the flow but has different consequences for trunk and tail extension. Modeling and additional data analyses suggest that the balance between the coherence and rate of cell flow determines whether body elongation is linear or whether congestion forms within the flow and the body axis becomes contorted.
机译：尾芽是正在生长的脊椎动物胚胎的后缘，由轴向骨骼，肌肉组织和脊髓的运动祖细胞组成。我们测量斑马鱼尾巴的3D细胞流场，并确定通过减少细胞运动的连贯性而不会改变细胞速度揭示的组织流动性变化。我们发现有向后流，其中单个细胞运动之间的极化很高，反映了有序的集体迁移。在尾巴的后部，由于单个细胞运动的方向可变性增加，这种流动使细胞大量混合，使双侧急转弯。 Wnt或Fgf信号或钙粘蛋白2功能的抑制会降低血流的连贯性，但对躯干和尾巴的延伸会产生不同的后果。建模和其他数据分析表明，细胞流动的相干性和速率之间的平衡决定了身体伸长率是否是线性的，或者在细胞流中是否形成拥塞并且身体轴是否扭曲。

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