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首页> 外文期刊>Development >Sertoli cells control peritubular myoid cell fate and support adult leydig cell development in the prepubertal testis
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Sertoli cells control peritubular myoid cell fate and support adult leydig cell development in the prepubertal testis

机译：支持细胞控制青春期前睾丸中肾小管周围肌样细胞的命运并支持成年莱迪格细胞的发育

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摘要

Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two transgenic mouse models that permit controlled, cell-specific ablation of SCs in pre-and postnatal life. Results show that SCs are required: (1) to maintain the differentiated phenotype of peritubular myoid cells (PTMCs) in prepubertal life; (2) to maintain the ALC progenitor population in the postnatal testis; and (3) for development of normal ALC numbers. Furthermore, our data show that fetal LCs function independently from SC, germ cell or PTMC support in the prepubertal testis. Together, these findings reveal that SCs remain essential regulators of testis development long after the period of sex determination. These findings have significant implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health.
机译：睾丸支持细胞（SCs）调节分化性腺中睾丸的命运，并且是成年睾丸中精子发生的主要调节剂。然而，它们在睾丸发育的中间阶段，特别是在成年Leydig细胞（ALC）分化和功能过程中的作用仍然未知。为了检查胎儿和青春期发育期间的SC功能，我们生成了两个转基因小鼠模型，可以在出生前和产后生活中对SC进行受控的细胞特异性消融。结果表明，SCs是必需的：（1）在青春期前维持肾小管周围肌样细胞（PTMCs）的分化表型; （2）维持产后睾丸中ALC祖细胞的数量; （3）开发正常的ALC编号。此外，我们的数据表明，胎儿LC的功能独立于青春期前睾丸中的SC，生殖细胞或PTMC支持。总之，这些发现表明，在性别确定时期之后，SC仍然是睾丸发育的重要调节器。这些发现对我们对男性生殖系统疾病和影响男性健康的更广泛的雄激素相关疾病的理解具有重要意义。

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