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首页> 外文期刊>Development >The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye
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The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye

机译：河马通路效应器Yki下调Wg信号以促进果蝇眼的视网膜分化。

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摘要

The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector of the Hippo signaling pathway, causes separable effects on growth and differentiation of the Drosophila eye. We present evidence supporting a role for Yki in suppressing eye fate by downregulation of the core retinal determination genes. Other upstream regulators of the Hippo pathway mediate this effect of Yki on retinal differentiation. Here, we show that, in the developing eye, Yki can prevent retinal differentiation by blocking morphogenetic furrow (MF) progression and R8 specification. The inhibition of MF progression is due to ectopic induction of Wingless (Wg) signaling and Homothorax (Hth), the negative regulators of eye development. Modulating Wg signaling can modify Yki-mediated suppression of eye fate. Furthermore, ectopic Hth induction due to Yki activation in the eye is dependent on Wg. Last, using Cut (Ct), a marker for the antennal fate, we show that suppression of eye fate by hyperactivation of yki does not change the cell fate (from eye to antenna-specific fate). In summary, we provide the genetic mechanism by which yki plays a role in cell fate specification and differentiation - a novel aspect of Yki function that is emerging from multiple model organisms.
机译：已知进化上保守的河马信号通路在发育过程中调节细胞增殖并维持组织稳态。我们发现激活约克（Yki），河马信号通路的效应器，对果蝇眼的生长和分化产生可分离的影响。我们目前的证据支持Yki通过下调核心视网膜测定基因来抑制眼球命运的作用。河马途径的其他上游调节剂介导Yki对视网膜分化的这种作用。在这里，我们表明，在发育中的眼中，Yki可以通过阻止形态发生犁沟（MF）进程和R8规范来防止视网膜分化。 MF进展的抑制是由于异位诱导Wingless（Wg）信号传导和Homothorax（Hth）（眼睛发育的负调节剂）引起的。调节Wg信号传导可以修饰Yki介导的对眼睛命运的抑制。此外，由于眼睛中Yki活化引起的异位Hth诱导取决于Wg。最后，使用Cut（Ct）（触角命运的标记），我们表明通过yki的过度激活抑制眼命运不会改变细胞的命运（从眼睛到天线特定的命运）。总之，我们提供了yki在细胞命运指定和分化中起作用的遗传机制-yki功能的一个新颖方面正在从多种模型生物中出现。

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