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首页> 外文期刊>Development >Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.
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Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.

机译：鞘氨醇-1-磷酸裂合酶在Disctyostelium discoideum的发展中起着核心作用。

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摘要

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.
机译：鞘氨醇降解的产物一磷酸鞘氨醇是调节细胞增殖和细胞死亡的信号转导途径的重要元素。我们已经证明了鞘氨醇-1-磷酸在生长和多细胞发育中的其他作用。鞘氨醇-1-磷酸裂解酶基因在盘基网柄菌中的特异破坏编码编码催化鞘氨醇-1-磷酸降解的酶，导致突变株具有异常的形态发生，并在固定期提高了活力。鞘氨醇-1-磷酸裂合酶的缺乏会影响整个发育的多个阶段，包括聚集细胞的细胞骨架结构，形成迁移子弹的能力以及细胞类型特异性基因表达和终生孢子分化的控制。这种多效性作用是由于鞘氨醇-1-磷酸裂合酶的丧失而引起的，在多种细胞发育过程中，鞘脂确立为关键调节分子。

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