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首页> 外文期刊>Development >Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
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Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

机译：脂肪小平面和液体小平面可促进信号传导细胞中的Delta内吞作用和Delta信号传导。

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摘要

Endocytosis modulates the Notch signaling pathway in both the signaling and receiving cells. One recent hypothesis is that endocytosis of the ligand Delta by the signaling cells is essential for Notch activation in the receiving cells. Here, we present evidence in strong support of this model. We show that in the developing Drosophila eye Fat facets (Faf), a deubiquitinating enzyme, and its substrate Liquid facets (Lqf), an endocytic epsin, promote Delta internalization and Delta signaling in the signaling cells. We demonstrate that while Lqf is necessary for three different Notch/Delta signaling events at the morphogenetic furrow, Faf is essential only for one: Delta signaling by photoreceptor precluster cells, which prevents recruitment of ectopic neurons. In addition, we show that the ubiquitin-ligase Neuralized (Neur), which ubiquitinates Delta, functions in the signaling cells with Faf and Lqf. The results presented bolster one model for Neur function in which Neur enhances Delta signaling by stimulating Delta internalization in the signaling cells. We propose that Faf plays a role similar to that of Neur in the Delta signaling cells. By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling.
机译：内吞作用调节信号和接收细胞中的Notch信号通路。最近的一种假设是，信号细胞对配体Delta的内吞作用对于接收细胞中的Notch激活是必不可少的。在这里，我们提供了对该模型的有力支持的证据。我们显示在果蝇眼中的脂肪小平面（Faf），一种去泛素化酶，及其底物液体小平面（Lqf），一种内吞性epsin，在信号传导细胞中促进Delta内部化和Delta信号传导。我们证明，虽然Lqf对于在形态发生犁沟中的三个不同的Notch / Delta信号事件是必需的，但Faf仅对以下一个条件是必不可少的：感光细胞前簇细胞的Delta信号，它阻止了异位神经元的募集。此外，我们显示泛素连接酶神经化（Neur），其泛素化Delta，在Faf和Lqf的信号传导细胞中起作用。结果显示了一种神经元功能模型，其中神经元通过刺激信号传导细胞中的Delta内部化来增强Delta信号传导。我们建议Faf在Delta信号传导细胞中起类似于Neur的作用。通过去泛素化Lqf（可增强Delta内在化的效率），Faf刺激Delta信号传导。

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