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首页> 外文期刊>Development >Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme.
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Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme.

机译：胚胎肌肉中快纤维和慢纤维的模式独立于周围间充质的信号而建立。

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摘要

During embryonic development, and before functional innervation, a highly stereotypic pattern of slow- and fast-contracting primary muscle fibers is established within individual muscles of the limbs, from distinct populations of myoblasts. A difference between the fiber-type pattern found within chicken and quail pectoral muscles was exploited to investigate the contributions of somite-derived myogenic precursors and lateral plate-derived mesenchymal stroma to the establishment of muscle fiber-type patterns. Chimeric chicken/quail embryos were constructed by reciprocal transplantation of somites or lateral plate mesoderm at stages prior to muscle formation. Muscle fibers derived from quail myogenic precursors that had migrated into chicken stroma showed a quail pattern of mixed fast- and slow-contracting muscle fibers. Conversely, chicken myogenic precursors that had migrated into quail stroma showed a chicken pattern of nearly exclusive fast muscle fiber formation. These results demonstrate in vivo an intrinsic commitment to fiber-type on the part of the myoblast, independent of extrinsic signals it receives from the mesenchymal stroma in which it differentiates.
机译：在胚胎发育过程中，以及在功能性神经支配之前，肢体的各个肌肉（来自成肌细胞的不同群体）都建立了缓慢收缩和快速收缩的初级肌肉纤维的高度定型模式。利用在鸡和鹌鹑的胸肌中发现的纤维类型模式之间的差异，来研究由体节来源的肌源性前体和侧板来源的间质基质对建立肌肉纤维类型模式的贡献。嵌合的鸡/鹌鹑胚胎是在肌肉形成之前的阶段通过相互移植体节或外侧板中胚层而构建的。源自鹌鹑成肌前体的肌肉纤维已经迁移到鸡基质中，表现出混合了快速收缩和缓慢收缩的肌肉纤维的鹌鹑模式。相反，已迁移到鹌鹑基质中的鸡肌原性前体显示出几乎排他的快速肌纤维形成的鸡模式。这些结果证明了成肌细胞部分对纤维类型的内在承诺，与它从分化的间充质基质接收到的外在信号无关。

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