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首页> 外文期刊>Development >Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.
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Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.

机译：局部Notch信号通过Eyg和Upd起作用，以促进果蝇眼的整体生长。

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摘要

Notch (N) signal is activated at the dorsoventral (DV) border of the Drosophila eye disc and is important for growth of the eye disc. In this study, we showed that the Pax protein Eyg is a major effector mediating the growth promotion function of N. eyg transcription is induced by N signaling occurring at the DV border. Like N, eyg controls growth of the eye disc. Loss of N signaling can be compensated by overexpressing eyg, whereas loss of the downstream eyg blocked the function of N signaling. In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation. Loss of eyg or N can be compensated by overexpressing upd. These results suggest that upd is a major effector mediating the function of eyg and N. The functional link from N to eyg to upd explains how the localized Notch activation can achieve global growth control.
机译：Notch（N）信号在果蝇眼盘的背腹（DV）边界处被激活，并且对于眼盘的生长很重要。在这项研究中，我们表明Pax蛋白Eyg是介导N. eyg转录的主要效应子。Eyg转录是由DV边界处的N信号传导诱导的。像N一样，eyg控制眼球的生长。 N信号的丢失可以通过过度表达eyg来补偿，而下游eyg的丢失会阻止N信号的功能。此外，我们表明N和eyg可以诱导upd的表达，其编码Jak / STAT途径的配体并在长距离上起作用以促进细胞增殖。 eyg或N的损失可以通过过表达upd来补偿。这些结果表明upd是介导eyg和N功能的主要效应子。从N到eyg到upd的功能联系解释了局部Notch激活如何实现整体生长控制。

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