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首页> 外文期刊>Development >Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity.
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Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity.

机译：通过细胞自主，有丝分裂后的Hox基因活性来特异性预防先锋神经元凋亡。

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In vertebrates, neurons often undergo apoptosis after differentiating and extending their axons. By contrast, in the developing nervous system of invertebrate embryos apoptosis typically occurs soon after cells are generated. Here, we show that the Drosophila dMP2 and MP1 pioneer neurons undergo segment-specific apoptosis at late embryonic stages, long after they have extended their axons and have performed their pioneering role in guiding follower axons. This segmental specificity is achieved by differential expression of the Hox gene Abdominal B, which in posterior segments prevents pioneer neuron death postmitotically and cell-autonomously by repressing the RHG-motif cell death activators reaper and grim. Our results identify the first clear case of a cell-autonomous and anti-apoptotic role for a Hox gene in vivo. In addition, they provide a novel mechanism linking Hox positional information to differences in neuronal architecture along the anteroposterior axis by the selective elimination of matureneurons.
机译：在脊椎动物中，神经元通常在分化和扩展其轴突后经历凋亡。相反，在无脊椎动物胚胎发育的神经系统中，细胞凋亡通常在细胞生成后不久发生。在这里，我们显示果蝇dMP2和MP1先锋神经元在其晚期轴突延伸并在指导跟随者轴突中发挥了先锋作用之后，就在胚胎晚期进入了节段特异性凋亡。这种分段特异性是通过Hox基因Abdominal B的差异表达来实现的，后者在后段中通过抑制RHG-motif细胞死亡激活剂的收割者和死亡来防止有丝分裂后和细胞自主的先驱神经元死亡。我们的研究结果确定了Hox基因在体内具有细胞自主和抗凋亡作用的第一个明确案例。此外，它们提供了一种新颖的机制，通过选择性消除成熟神经元，将Hox位置信息与沿前后轴的神经元结构差异联系起来。

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