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首页> 外文期刊>Development >Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny.
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Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny.

机译：间充质祖细胞在整个个体发育过程中位于造血部位。

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Mesenchymal stem cells (MSCs) have great clinical potential for the replacement and regeneration of diseased or damaged tissue. They are especially important in the production of the hematopoietic microenvironment, which regulates the maintenance and differentiation of hematopoietic stem cells (HSCs). In the adult, MSCs and their differentiating progeny are found predominantly in the bone marrow (BM). However, it is as yet unknown in which embryonic tissues MSCs reside and whether there is a localized association of these cells within hematopoietic sites during development. To investigate the embryonic origins of these cells, we performed anatomical mapping and frequency analysis of mesenchymal progenitors at several stages of mouse ontogeny. We report here the presence of mesenchymal progenitors, with the potential to differentiate into cells of the osteogenic, adipogenic and chondrogenic lineages, in most of the sites harboring hematopoietic cells. They first appear in the aorta-gonad-mesonephros (AGM) region at the time of HSC emergence. However, at this developmental stage, their presence is independent of HSC activity. They increase numerically during development to a plateau level found in adult BM. Additionally, mesenchymal progenitors are found in the embryonic circulation. Taken together, these data show a co-localization of mesenchymal progenitor/stem cells to the major hematopoietic territories, suggesting that, as development proceeds, mesenchymal progenitors expand within these potent hematopoietic sites.
机译：间充质干细胞（MSCs）在疾病或受损组织的置换和再生方面具有巨大的临床潜力。它们在造血微环境的产生中特别重要，该环境调节造血干细胞（HSC）的维持和分化。在成体中，MSC及其分化后代主要在骨髓（BM）中发现。但是，尚不清楚MSCs驻留在哪个胚胎组织中，以及这些细胞在发育过程中在造血部位内是否存在局部结合。为了研究这些细胞的胚胎起源，我们在小鼠个体发育的几个阶段进行了间充质祖细胞的解剖图谱和频率分析。我们在此报告了间充质祖细胞的存在，在大多数造血细胞的位点中，有可能分化为成骨，成脂和成软骨谱系的细胞。它们在HSC出现时首先出现在主动脉-性腺-中肾（AGM）区域。但是，在这个发育阶段，它们的存在与HSC活性无关。它们在发育过程中数字增加到成年BM中的平稳水平。另外，在胚胎循环中发现间充质祖细胞。综上所述，这些数据显示了间充质祖细胞/干细胞在主要造血区域的共定位，表明随着发育的进行，间充质祖细胞在这些有效的造血部位内扩展。

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