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首页> 外文期刊>Development >The Drosophila lymph gland as a developmental model of hematopoiesis.
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The Drosophila lymph gland as a developmental model of hematopoiesis.

机译：果蝇淋巴腺是造血功能的发展模型。

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Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a framework for the identification of Drosophila blood cells, at various stages of maturation, and provides a genetic basis for spatial and temporal events that govern hemocyte development. The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis.
机译：果蝇造血发生在称为淋巴腺的特殊器官中。在对淋巴腺结构和基因表达的系统分析中，我们定义了血细胞（血细胞）前体成熟的发育步骤。特别地，描述了在造血过程中淋巴腺中血细胞成熟，信号传导和增殖的不同区域。血细胞发育的不同阶段已根据标志物的表达进行了分类，并置于发育壁ni中：静止的血细胞的髓质区，成熟的血细胞的皮层区和称为特殊信号血细胞的后信号中心。这建立了在成熟的各个阶段鉴定果蝇血细胞的框架，并为控制血细胞发育的时空事件提供了遗传基础。在该分析中鉴定的细胞事件进一步将果蝇确立为造血作用的模型系统。

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