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首页> 外文期刊>Basic & clinical pharmacology & toxicology. >Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats.
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Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats.

机译：抗糖尿病药物在链脲佐菌素-烟酰胺诱导的轻度糖尿病大鼠和链脲佐菌素-诱导的严重糖尿病大鼠中的降血糖作用。

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In this study, streptozotocin-induced severely diabetic rats and streptozotocin-nicotinamide-induced mildly diabetic rats were established to compare their characteristics and to investigate the hypoglycaemic effects of antidiabetic drugs. Results show that in streptozotocin-induced severely diabetic rats, the pancreatic insulin content decreased to approximately 10% of that in normal rats. These severely diabetic rats also exhibited marked hyperglycaemia and impaired glucose tolerance due to insulin secretory deficiency. In contrast, the pancreatic insulin content was approximately 50% of normal levels in streptozotocin-nicotinamide-induced mildly diabetic rats. These mildly diabetic rats exhibited moderate hyperglycaemia and impaired glucose tolerance due to loss of early-phase insulin secretion. Voglibose (alpha-glucosidase inhibitor), metformin (biguanide), glibenclamide (sulfonylurea), sitagliptin (dipeptidyl peptidase-4 inhibitor) and insulin significantly improved glucose tolerance in streptozotocin-nicotinamide-induced mildly diabetic rats. In contrast, in streptozotocin-induced severely diabetic rats, voglibose, metformin and insulin significantly improved glucose tolerance, but no significant effect was observed for glibenclamide and sitagliptin due to a decreased insulinotropic effect. These results suggest that streptozotocin-nicotinamide-induced mildly diabetic rats, which exhibit a mild decline in glucose tolerance due to loss of early-phase insulin secretion, are sensitive to the hypoglycaemic effects of insulinotropic agents and have many pathological features resembling type 2 diabetes, which may be useful in the pharmacological investigation of numerous antidiabetic drugs.
机译：在这项研究中，建立了链脲佐菌素诱导的严重糖尿病大鼠和链脲佐菌素-烟酰胺引起的轻度糖尿病大鼠，以比较它们的特征并研究抗糖尿病药的降血糖作用。结果显示，在链脲佐菌素诱导的重度糖尿病大鼠中，胰腺胰岛素含量降至正常大鼠的约10％。这些严重的糖尿病大鼠还由于胰岛素分泌不足而表现出明显的高血糖症和葡萄糖耐量受损。相反，在链脲佐菌素-烟酰胺诱导的轻度糖尿病大鼠中，胰腺胰岛素含量约为正常水平的50％。由于早期胰岛素分泌的丧失，这些轻度糖尿病大鼠表现出中度高血糖和葡萄糖耐量受损。伏格列波糖（α-葡萄糖苷酶抑制剂），二甲双胍（双胍），格列本脲（磺酰脲），西他列汀（二肽基肽酶-4抑制剂）和胰岛素显着改善了链脲佐菌素-烟酰胺引起的轻度糖尿病大鼠的葡萄糖耐量。相反，在链脲佐菌素诱导的严重糖尿病大鼠中，伏格列波糖，二甲双胍和胰岛素显着改善了葡萄糖耐量，但由于降低了促胰岛素作用，未观察到格列本脲和西他列汀的显着作用。这些结果表明，链脲佐菌素-烟酰胺诱导的轻度糖尿病大鼠由于早期胰岛素分泌的丧失而表现出葡萄糖耐量的轻度下降，对促胰岛素药的降血糖作用敏感，并具有许多类似于2型糖尿病的病理特征，在许多抗糖尿病药的药理研究中可能有用。

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