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首页> 外文期刊>Development >A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure.
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A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure.

机译：环状核苷酸门控通道抑制幼虫和成年秀丽隐杆线虫的感觉轴突生长：维持感觉轴突结构的独特途径。

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摘要

The tax-2 and tax-4 genes of C. elegans encode two subunits of a cyclic nucleotide-gated channel that is required for chemosensation, thermosensation and normal axon outgrowth of some sensory neurons. Here we show that, in tax-2 and tax-4 mutants, young larvae have superficially normal axons, but axon outgrowth resumes in inappropriate regions in late larval stages. Using a temperature-sensitive mutation in tax-2, we find that tax-2 activity is required during the adult stage to preserve normal axon morphology. These results indicate that tax-2 and tax-4 are required for the maintenance of correct axon structure, and reveal an unexpected plasticity that allows C. elegans axons to be remodeled long after their initial connections have been established. TAX-2 and TAX-4 have been proposed to form a transduction channel for chemosensation and thermosensation, and tax-2 activity is required in the adult stage for normal chemotaxis to NaCl and odorants. Animals mutant for the daf-11 gene have axon phenotypes that are similar to those of tax-2 and tax 4 mutants; this axon phenotype also has a late time of action. daf-11 regulates a developmental process called dauer larva formation that is controlled by sensory stimuli, and tax-2 and tax-4 can either stimulate or inhibit dauer larva formation in different contexts.
机译：秀丽隐杆线虫的tax-2和tax-4基因编码环核苷酸门控通道的两个亚基，这是一些感觉神经元的化学感应，热敏和正常轴突生长所必需的。在这里，我们显示，在tax-2和tax-4突变体中，幼虫的幼虫具有表面上正常的轴突，但是在幼虫后期，轴突的生长在不适当的区域恢复。使用tax-2的温度敏感突变，我们发现在成年阶段需要tax-2活性才能保持正常的轴突形态。这些结果表明，tax-2和tax-4是维持正确的轴突结构所必需的，并显示出出乎意料的可塑性，这使秀丽隐杆线虫的轴突在建立初始连接后很长一段时间就可以重塑。已经建议使用TAX-2和TAX-4形成化学传感和热敏的转导通道，并且在成年阶段需要tax-2活性才能正常地对NaCl和增香剂进行化学趋化。 daf-11基因突变的动物的轴突表型与tax-2和tax 4突变体相似。该轴突表型也具有较晚的作用时间。 daf-11调节由感觉刺激控制的称为dauer幼虫形成的发育过程，而tax-2和tax-4可以在不同情况下刺激或抑制dauer幼虫形成。

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