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首页> 外文期刊>Development >The ectodysplasin pathway in feather tract development.
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The ectodysplasin pathway in feather tract development.

机译：羽管发育中的外生质素途径。

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摘要

The ectodysplasin pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role in epidermal organ formation in mammals. Mutations in the genes encoding these proteins cause dysplasia or absence of teeth, sweat glands and hair follicles. However, the relative position of this pathway in the regulatory hierarchy directing follicle formation remains unclear. In this work, the chicken orthologs of Eda, Edar and Edaradd were cloned to exploit the temporal precision of the feather tract system in order to study the role of the ectodysplasin pathway. We find that these genes are expressed in a similar pattern during feather and hair development, with the notable difference that the ligand Eda, which is expressed in the epidermis of the mouse, is expressed in the dermis of the feather tract. Contrary to conclusions reached from the analysis of mutant mice, we find that localization of Edar expression to the nascent placode is coincident or subsequent to the local expression of other markers of placodal differentiation, and not an upstream event in tract patterning. Furthermore, forced expression of BMP and activated beta-catenin demonstrate that local expression of Edar is dictated by the interaction between these two pathways. These results suggest that activation of the ectodysplasin pathway may be permissive for activating signals to overcome signals that inhibit placode formation, but the function of this pathway in the specification of follicle initiation lies downstream of other patterning events.
机译：包含配体ectodysplasin，其受体Edar和专用死亡域衔接蛋白Edaradd的ectodysplasin途径在哺乳动物表皮器官形成中起重要作用。编码这些蛋白质的基因突变会导致牙齿，汗腺和毛囊发育不良或缺失。然而，该途径在指导卵泡形成的调控体系中的相对位置仍不清楚。在这项工作中，克隆了Eda，Edar和Edaradd的鸡直系同源物，以利用羽毛道系统的时间精度，以研究外生质素途径的作用。我们发现这些基因在羽毛和头发发育过程中以相似的模式表达，其显着区别是在小鼠表皮中表达的配体Eda在羽毛道的真皮中表达。与从突变小鼠的分析得出的结论相反，我们发现Edar表达在新生斑块上的定位与其他斑状分化标记物同时发生或在局部表达之后发生，而不是在管道模式中出现上游事件。此外，BMP和活化的β-catenin的强制表达表明，Edar的局部表达受这两种途径之间的相互作用所决定。这些结果表明，胞外质素途径的激活可能是激活信号以克服抑制斑块形成的信号所允许的，但是该途径在卵泡起始过程中的功能位于其他构图事件的下游。

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