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首页> 外文期刊>Development >A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.
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A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.

机译:动态的前脑命运图显示了脊椎动物的眼睛是如何形成的,并解释了引起眼睑倾斜的两种原因。

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摘要

Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.
机译:人们对在发育过程中形成和折叠细胞片的机制了解甚少。一个例子是在训练过程中前脑神经板的复杂重组,必须将薄片折叠成试管,同时使两只眼从神经板内的单个连续区域中抽出。我们第一次跟踪这些细胞重排,以显示前脑形态发生与先前的假设有显着差异。我们假定一个新模型的前脑神经元,并证明影响两个信号通路的突变如何通过破坏正常的细胞运动或引入新的错误行为而产生环视表型。

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