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首页> 外文期刊>Developmental disabilities research reviews. >Potential influences on mathematical difficulties in children and adolescents with neurofibromatosis, type 1.
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Potential influences on mathematical difficulties in children and adolescents with neurofibromatosis, type 1.

机译：对1型神经纤维瘤病儿童和青少年数学上的困难的潜在影响。

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摘要

Neurofibromatosis, type 1 (NF-1) is a common genetic disorder affecting 1 in 3,500-4,000 individuals in the world. Mutations of the NF-1 gene produce a myriad of physical, medical, and psychological manifestations. Although there is a very high degree of variability in the manifestations between individuals with NF-1, the majority of children and adolescents with NF-1 encounter difficulties that negatively impact their educational attainment. NF-1 is associated with a very high incidence of cognitive deficits and learning disability, sometimes including mathematical learning disabilities (MLD). A number of possible inter-related etiologies for MLD specific to children and adolescents with NF-1 are discussed, including the high incidence of attention deficit hyperactivity disorder, visual spatial impairment, morphological and functional brain abnormalities. Thus NF-1 exemplifies the wide ranging sources of potential influences on mathematical learning and MLD.
机译：1型神经纤维瘤病（NF-1）是一种常见的遗传性疾病，影响全世界3,500-4,000个人中的1个人。 NF-1基因的突变产生无数的身体，医学和心理表现。尽管NF-1个体之间的表现差异很大，但是大多数NF-1的儿童和青少年遇到的困难对他们的教育程度产生负面影响。 NF-1与认知缺陷和学习障碍的发生率很高，有时包括数学学习障碍（MLD）。讨论了许多特定于NF-1的儿童和青少年的MLD可能相互关联的病因，包括注意缺陷多动障碍，视觉空间障碍，大脑形态和功能异常的高发生率。因此，NF-1体现了对数学学习和MLD潜在影响的广泛来源。

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