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首页> 外文期刊>Developmental dynamics: an official publication of the American Association of Anatomists >Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord
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Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord

机译：Nogo-A，MAG和NgR在再生尿路脊髓中的表达模式

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摘要

Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847-860, 2013.
机译：背景：哺乳动物中枢神经系统在损伤后无法进行实质性轴突再生，部分原因是存在包括Nogo-A和髓磷脂相关糖蛋白（MAG）在内的髓磷脂相关抑制分子。相比之下，a在脊髓再生期间能够使轴突再生长。结果：在这里，我们显示Nogo-A和MAG及其受体Nogo受体（NgR）存在于x基因组中，并在发育，成年以及重要的是在中枢神经系统（CNS）中广泛表达再生。此外，我们显示Nogo-A和NgR在Sox2阳性神经祖细胞中共表达。结论：这些表达模式表明髓鞘相关蛋白允许a的神经发育和再生。发展动态242：847-860，2013。

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