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首页> 外文期刊>Developmental immunology >Balancing thymocyte adhesion and motility: a functional linkage between beta1 integrins and the motility receptor RHAMM.
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Balancing thymocyte adhesion and motility: a functional linkage between beta1 integrins and the motility receptor RHAMM.

机译：平衡胸腺细胞粘附和运动性：beta1整合素和运动性受体RHAMM之间的功能联系。

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Thymocyte differentiation involves several processes that occur in different anatomic sites within the thymus. Therefore, thymocytes must have the ability to respond to signals received from stromal cells and adopt either adhesive or motile behavior. We will discuss our data indicating human thymocytes use alpha4beta1 integrin, alpha5beta1 integrin and RHAMM to mediate these activities. Immature multinegative (MN; CD3-4-8-19-) thymocytes use alpha4beta1 and alpha5beta1 integrins to mediate weak and strong adhesion. This subset also uses alpha4beta1 integrin to mediate motility. As thymocytes differentiate, they begin to express and use RHAMM to mediate motility in conjunction with alpha4beta1 and alpha5beta1 integrins. Motile thymocytes use beta1 integrins to maintain weakly adhesive contacts with substrate to provide traction for locomoting cells, thus weak adhesion is a requirement of motile behavior. Hyaluronan (HA) is also required by thymocytes to mediate motility. HA binding to cell surface RHAMM redistributes intracellular RHAMM to the cell surface where it functions to mediate motility. We propose that the decision to maintain adhesive or motile behavior is based on the balance between low and high avidity binding conformations of beta1 integrins on thymocytes and that RHAMM:HA interactions decrease high avidity binding conformations of integrins pushing the balance toward motile behavior.
机译：胸腺细胞分化涉及在胸腺内不同解剖部位发生的几个过程。因此，胸腺细胞必须具有响应从基质细胞收到的信号并采取粘附或运动行为的能力。我们将讨论表明人类胸腺细胞使用alpha4beta1整合素，alpha5beta1整合素和RHAMM介导这些活动的数据。不成熟的多阴性（MN; CD3-4-8-19-）胸腺细胞使用alpha4beta1和alpha5beta1整合素介导弱而强的粘附。该子集还使用alpha4beta1整合素来介导运动。随着胸腺细胞的分化，它们开始表达并使用RHAMM与alpha4beta1和alpha5beta1整合素一起介导运动。运动性胸腺细胞使用beta1整联蛋白来维持与底物的弱粘合接触，从而为运动细胞提供牵引力，因此，弱粘合性是运动行为的必要条件。胸腺细胞也需要透明质酸（HA）来调节运动能力。与细胞表面RHAMM结合的HA将细胞内RHAMM重新分布到细胞表面，在其中它发挥调解运动性的作用。我们建议维持黏附或运动行为的决定是基于胸腺细胞上β1整联蛋白的低和高亲和力结合构象之间的平衡，而RHAMM：HA相互作用会降低整联蛋白的高亲和力结合构象，从而将平衡推向运动行为。

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