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首页> 外文期刊>Developmental immunology >Incidence of apoptosis in the lymphoid organs of normal or malaria infected mice is decreased in CD18 and urokinase-receptor (UPAR, CD87) deficient mice.
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Incidence of apoptosis in the lymphoid organs of normal or malaria infected mice is decreased in CD18 and urokinase-receptor (UPAR, CD87) deficient mice.

机译：正常或疟疾感染小鼠的淋巴器官中凋亡的发生率在CD18和尿激酶受体（UPAR，CD87）缺陷小鼠中降低。

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摘要

Incidence of apoptosis was investigated in the spleen and lymph nodes of +/+, CD18 -/- and urokinase receptor (uPAR, CD87) -/- mice, untreated or Plasmodium Berghei Anka (PbA) infected. In non infected mice, incidence of apoptosis was lower in the lymph nodes of CD18 -/- and uPAR -/- than in +/+ mice, as seen by FACS analysis to count the number of hypodiploid and Annexin-V binding cells. Infection of mice with PbA resulted in a marked increase in the size of spleen and lymph nodes 7-8 days after infection, which was slightly higher in uPAR -/- and CD 18 -/- than in +/+ mice. PbA infection increased about 7 fold the incidence of apoptosis in the lymphoid organs of +/+, especially in the white pulp and germinal centers of the spleen and lymph nodes, while in contrast it was unchanged in PbA infected CD 18 -/- or uPAR -/- mice. Serum IgG levels, and number of circulating leukocytes were significantly higher in both uPAR and CD18 -/- than in +/+ mice. These results indicate that the CD18 and uPAR surface molecules, which are known to be associated in the cell membrane, have an important influence upon the incidence of cell survival in both normal or stimulated lymphoid organs.
机译：在未经治疗或感染了伯氏疟原虫（PbA）的+ / +，CD18-/-和尿激酶受体（uPAR，CD87）-/-小鼠的脾脏和淋巴结中研究了细胞凋亡的发生率。通过FACS分析计数二倍体和膜联蛋白-V结合细胞的数量，在未感染的小鼠中，CD18-/-和uPAR-/-的淋巴结中凋亡的发生率比+ / +小鼠低。用PbA感染小鼠会导致感染后7-8天脾脏和淋巴结大小明显增加，在uPAR-/-和CD 18-/-中比在+ / +小鼠中稍高。 PbA感染使+ / +的淋巴器官的细胞凋亡发生率增加了约7倍，尤其是在白髓和脾脏及淋巴结的生发中心，而相比之下，在受PbA感染的CD 18-/-或uPAR中则没有变化-/- 老鼠。 uPAR和CD18-/-的血清IgG水平和循环白细胞数量均显着高于+ / +小鼠。这些结果表明，已知与细胞膜相关的CD18和uPAR表面分子对正常或受刺激的淋巴器官的细胞存活率都有重要影响。

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