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首页> 外文期刊>Diabetes & metabolic syndrome. >Serum adipokine profile in Indian men with nonalcoholic steatohepatitis: Serum adiponectin is paradoxically decreased in lean vs. obese patients
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Serum adipokine profile in Indian men with nonalcoholic steatohepatitis: Serum adiponectin is paradoxically decreased in lean vs. obese patients

机译：非酒精性脂肪性肝炎的印度裔男性的血清脂肪因子特征：瘦与肥胖患者血清脂联素反常下降

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Background: Asian Indians are known to be more insulin resistant for the same degree of weight gain. It is therefore likely that the adipokine profile in nonalcoholic fatty liver disease (NAFLD) in Asian Indian population could be different from the Western subjects. Aims: To study the serum adiponectin, resistin, leptin and TNF-alpha profile in NAFLD and cryptogenic cirrhosis patients. Subjects and methods: Body mass indices, insulin resistance and serum adipokine levels were studied in 56 patients; 10 with fatty liver, 30 with nonalcoholic steatohepatitis (NASH) and 16 with cryptogenic cirrhosis. Eighteen healthy controls were also included. Results: Patients in general were obese compared to controls (mean BMI 26.9 +- 4.5 vs. 22.6 +- 2.5, respectively, p < 0.0001). In patients with NASH, adiponectin levels were lower than controls (5.4 +- 3 mug/ml vs.7.2 +- 2.9 mug/ml, p = 0.037). Insulin Resistance as assessed by homeostasis model assessment (HOMA) was higher in obese than lean, NAFLD patients (HOMA IR obese, median = 2.8, range = 0.8-16.3 and lean: median = 1.05, range = 0.51-2.75, p = 0.003). Lean NAFLD patients had adiponectin levels lower than obese patients (3 +- 1 mug/ml vs.6.7 +- 3.8 mug/ml respectively, p = 0.003). Serum resistin levels were higher in NAFLD patients (3.7 +- 3 ng/ml) than controls (2.1 +-1.7 ng/ml, p = 0.007). This difference was significant even when cirrhotic patients were excluded (3.4 +- 2.7 ng/ml, p = 0.036). Serum leptin levels were raised in cryptogentic cirrhosis compared to NASH (p = 0.03). All adipokines tested were raised in cirrhotic patients compared to NAFLD and controls. Conclusions: A significant reduction in serum adiponectin and increase in serum resistin levels were observed in NAFLD patients, more so in lean than obese NAFLD. This paradoxical decrease of serum adiponectin as well as low frequency of insulin resistance in lean NAFLD suggests a possible different etiology for this subset of patients.
机译：背景：已知亚洲印第安人在相同程度的体重增加中对胰岛素的抵抗力更高。因此，亚洲印度裔人群中非酒精性脂肪肝疾病（NAFLD）中的脂肪因子分布可能与西方受试者有所不同。目的：研究NAFLD和隐源性肝硬化患者的血清脂联素，抵抗素，瘦素和TNF-α谱。对象和方法：研究了56名患者的体重指数，胰岛素抵抗和血清脂肪因子水平。脂肪肝10例，非酒精性脂肪性肝炎（NASH）30例，隐源性肝硬化16例。还包括十八个健康对照。结果：与对照组相比，患者总体肥胖（BMI平均分别为26.9±4.5和22.6±2.5，p <0.0001）。在患有NASH的患者中，脂联素水平低于对照组（5.4±3杯/毫升vs. 7.2 + 2.9杯/毫升，p = 0.037）。通过稳态模型评估（HOMA）评估的肥胖患者的胰岛素抵抗高于瘦的NAFLD患者（HOMA IR肥胖，中位数= 2.8，范围= 0.8-16.3和瘦：中位数= 1.05，范围= 0.51-2.75，p = 0.003 ）。瘦的NAFLD患者的脂联素水平低于肥胖患者（分别为3 +1杯/毫升和6.7 +/- 3.8杯/毫升，p = 0.003）。 NAFLD患者的血清抵抗素水平（3.7±3 ng / ml）高于对照组（2.1±-1.7 ng / ml，p = 0.007）。即使排除肝硬化患者，这种差异也很显着（3.4±2.7 ng / ml，p = 0.036）。与NASH相比，隐源性肝硬化患者的血清瘦素水平升高（p = 0.03）。与NAFLD和对照组相比，肝硬化患者的所有脂肪因子均升高。结论：在NAFLD患者中观察到血清脂联素显着降低和血清抵抗素水平升高，瘦者比肥胖者更明显。贫脂性NAFLD患者血清脂联素的这种自相矛盾的减少以及胰岛素抵抗的低频率表明，这部分患者可能有不同的病因。

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