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首页> 外文期刊>Diabetes care >Heterogeneity of responses to real-time continuous glucose monitoring (RT-CGM) in patients with type 2 diabetes and its implications for application
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Heterogeneity of responses to real-time continuous glucose monitoring (RT-CGM) in patients with type 2 diabetes and its implications for application

机译：2型糖尿病患者对实时连续血糖监测（RT-CGM）的反应异质性及其应用意义

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OBJECTIVE-To characterize glucose response patterns of people who wore a real-time continuous glucose monitor (RT-CGM) as an intervention to improve glycemic control. Participants had type 2 diabetes, were not taking prandial insulin, and interpreted the RT-CGM data independently. RESEARCH DESIGN AND METHODS-Data were from the first 12 weeks of a 52-week, prospective, randomized trial comparing RT-CGM (n = 50) with self-monitoring of blood glucose (n = 50). RT-CGMwas used in 8 of the first 12weeks. A1C was collected at baseline and quarterly. This analysis included 45 participants who wore the RT-CGM??4 weeks. Analyses examined the RT-CGM data for common response patterns-a novel approach in this area of research. It then used multilevel models for longitudinal data, regression, and nonparametric methods to compare the patterns of A1C, mean glucose, glycemic variability, and views per day of the RT-CGM device. RESULTS-There were five patterns. For four patterns,mean glucose was lower than expected as of the first RT-CGM cycle of use given participants' baseline A1C. We named them favorable response but with high and variable glucose (n = 7); tight control (n = 14); worsening glycemia (n = 6); and incremental improvement (n = 11). The fifth was no response (n = 7). A1C, mean glucose, glycemic variability, and views per day differed across patterns at baseline and longitudinally. CONCLUSIONS-The patterns identified suggest that targeting people with higher starting A1Cs, using it short-term (e.g., 2 weeks), and monitoring for worsening glycemia that might be the result of burnout may be the best approach to using RT-CGM in people with type 2 diabetes not taking prandial insulin. ? 2013 by the American Diabetes Association.
机译：目的-表征佩戴实时连续血糖监测仪（RT-CGM）的人的血糖反应模式，以改善血糖控制。参与者患有2型糖尿病，不服用餐前胰岛素，并独立解释RT-CGM数据。研究设计和方法-数据来自一项为期52周的前瞻性随机试验，该试验将RT-CGM（n = 50）与血糖自我监测（n = 50）进行了比较。前12周中有8周使用了RT-CGM。在基线和季度收集A1C。这项分析包括45位参加RT-CGM ?? 4周的参与者。分析人员检查了RT-CGM数据的常见响应模式-这是该研究领域中的一种新颖方法。然后，它使用多级模型进行纵向数据分析，回归分析和非参数方法，以比较A1C的模式，平均血糖，血糖变异性和RT-CGM设备每天的观看次数。结果-有五种模式。对于四种模式，在给定参与者基线A1C的情况下，自使用的第一个RT-CGM周期以来，平均血糖低于预期。我们称它们为良好的反应，但葡萄糖含量高且变化多（n = 7）;严格控制（n = 14）;血糖升高（n = 6）;和逐步改善（n = 11）。第五位无反应（n = 7）。 A1C，平均血糖，血糖变异性和每天的观看次数在基线和纵向的模式上有所不同。结论-确定的模式表明，以较高的A1C起始人群为目标人群，短期使用（例如2周），监测可能因倦怠而导致的血糖恶化，可能是在人群中使用RT-CGM的最佳方法2型糖尿病患者不服用餐前胰岛素。 ？ 2013年由美国糖尿病协会颁发。

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