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首页> 外文期刊>Diabetes care >Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway
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Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway

机译：年轻健康女性中成纤维细胞生长因子21的水平显示昼夜变化，并通过与瘦素无关的途径对短期能量剥夺作出响应而增加

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OBJECTIVE-Fibroblast growth factor (FGF)-21 is an endocrine factor with potentmetabolic effects. Its day-night patterns of secretion and/or its physiological response to energy deprivation and relationship to free fatty acids (FFAs) and/or leptin remain to be fully elucidated.We aim to elucidate day-night pattern of FGF-21 levels and its relationship to FFA, to assesswhether energy deprivation alters its circulating patterns, and to examine whether leptin may mediate these changes. RESEARCH DESIGN AND METHODS-Six healthy lean females were studied for 72 h in a cross-over interventional study under three different conditions: on isocaloric diet and in a fasting state with administration of either placebo or metreleptin in physiological replacement doses. Blood samples were obtained hourly from 8:00 A.M. on day 4 until 8:00 A.M. on day 5. RESULTS-FGF-21 exhibited day-night variation pattern during the isocaloric fed state. Fasting significantly increased FGF-21 levels (P < 0.01) via a leptin-independent pathway. Day-night variation pattern in the fed state was lost on fasting. Leptin replacement in the hypoleptinemic state restored approximate entropy of FGF-21 time series but did not alter circulating levels. FGF-21 levels were closely cross-correlated with FFA levels in all three states. CONCLUSIONS-A day-night variation in the levels of FGF-21 exists in young lean females in the fed state. Energy deprivation increases FGF-21 levels via a leptin-independent pathway. The interaction between FGF-21 and starvation-induced lipolysis, as indicated by its close crosscorrelations with FFA in both fed state and energy deprivation, needs to be studied further. ? 2013 by the American Diabetes Association.
机译：目标成纤维细胞生长因子（FGF）-21是具有潜在代谢作用的内分泌因子。其昼夜分泌模式和/或其对能量剥夺的生理反应以及与游离脂肪酸（FFA）和/或瘦素的关系仍有待充分阐明。我们旨在阐明FGF-21水平及其昼夜模式与FFA的关系，以评估能量消耗是否会改变其循环模式，并检查瘦素是否可以介导这些变化。研究设计与方法在一项交叉干预研究中，对六名健康的瘦女性进行了72小时的研究，该研究在以下三种不同条件下进行：等热量饮食和空腹状态下以生理替代剂量服用安慰剂或美特洛汀。从上午8:00开始每小时采集一次血液样本。在第4天直到上午8:00在第5天。结果-FGF-21在等热量进食状态期间表现出昼夜变化模式。空腹通过瘦素非依赖性途径显着增加FGF-21水平（P <0.01）。进食状态下的昼夜变化模式在禁食时丢失。瘦素状态下的瘦素替代恢复了FGF-21时间序列的近似熵，但没有改变循环水平。在所有三个州中，FGF-21水平与FFA水平密切相关。结论：在成年状态的年轻瘦女性中，FGF-21水平存在昼夜变化。能量缺乏通过瘦素非依赖性途径增加FGF-21水平。 FGF-21与饥饿诱导的脂解之间的相互作用，正如其在进食状态和能量缺乏时与FFA的密切相互关系所表明的，需要进一步研究。 ？ 2013年由美国糖尿病协会颁发。

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