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首页> 外文期刊>Diabetes care >Glycemia, insulin resistance, insulin secretion, and risk of depressive symptoms in middle age
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Glycemia, insulin resistance, insulin secretion, and risk of depressive symptoms in middle age

机译：血糖升高，胰岛素抵抗，胰岛素分泌和中年抑郁症状的风险

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OBJECTIVE-The extent to which abnormal glucose metabolism increases the risk of depression remains unclear. In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS). RESEARCH DESIGN AND METHODS-In this prospective cohort study of 3,145 adults fromtheWhitehall II Study (23.5%women, aged 60.665.9 years), baseline examination included fasting glucose and insulin level, the homeostasismodel assessment of insulin resistance (HOMA2-%IR), and the homeostasis model assessment of ??-cell insulin secretion (HOMA2-% B). DepS (Center for Epidemiologic Studies Depression Scale??16 or use of antidepressive drugs) were assessed at baseline and at 5-year follow-up. RESULTS-Over the 5-year follow-up, DepS developed in 142 men and 84 women. Women in the lowest quintile of insulin secretion (HOMA2-%B <55.3%) had 2.18 (95% CI 1.25-3.78) times higher odds of developing DepS than those with higher insulin secretion. This association was not accounted for by inflammatory markers, cortisol secretion, or menopausal status and hormone replacement therapy. Fasting insulin measures were not associated with DepS in men, and fasting glucose measures were not associated with new-onset DepS in either sex. CONCLUSIONS-Low insulin secretion appears to be a risk factor for DepS in middle-aged women, although further work is required to confirm this finding. ? 2013 by the American Diabetes Association.
机译：目的-葡萄糖代谢异常增加增加患抑郁症风险的程度尚不清楚。在这项研究中，我们调查了空腹血糖和空腹胰岛素水平以及胰岛素抵抗和分泌指数与随后的新发抑郁症状（DepS）的前瞻性关联。研究设计和方法-在这项来自Whitehall II研究的3145名成年人（23.5％的妇女，年龄60.665.9岁）的前瞻性队列研究中，基线检查包括空腹血糖和胰岛素水平，胰岛素抵抗的稳态模型评估（HOMA2-％IR），和稳态模型评估β-细胞胰岛素分泌（HOMA2-％B）。在基线和5年随访时评估DepS（流行病学研究中心抑郁量表?? 16或使用抗抑郁药）。结果-在5年的随访中，DepS在142名男性和84名女性中发展。胰岛素分泌最低的五分之一女性（HOMA2-％B <55.3％）患DepS的几率是胰岛素分泌高的女性的2.18倍（95％CI 1.25-3.78）。炎症标志物，皮质醇分泌或绝经状态和激素替代疗法不能解释这种关联。男性空腹胰岛素测量与DepS无关，空腹血糖测量与男女新发DepS不相关。结论低胰岛素分泌似乎是中年女性DepS的危险因素，尽管还需要进一步的工作来证实这一发现。 ？ 2013年由美国糖尿病协会颁发。

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