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首页> 外文期刊>Diabetes care >Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: A 5-year follow-up study
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Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: A 5-year follow-up study

机译：血清铁蛋白与韩国中年男性代谢综合征发生的关联：一项为期5年的随访研究

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OBJECTIVE - Elevated serum ferritin has been known to be associated with the prevalence of metabolic syndrome (MetS). However, there was no research to examine whether serum ferritin levels have been actually associated with the prospective development of MetS. Accordingly, we carried out a prospective study to evaluate the longitudinal effects of baseline serumferritin levels on the development of MetS. RESEARCH DESIGN AND METHODS - A MetS-free cohort of 18,022 healthy Korean men, who had participated in a medical health checkup program in 2005, was followed until 2010. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Cox proportional hazards models were performed. RESULTS - During 45,919.3 person-years of follow-up, 2,127 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95%CI) for incident MetS comparing the second quintile to the fifth quintile of serumferritin levels versus the first quintile were 1.19 (0.98-1.45), 1.17 (0.96-1.43), 1.36 (1.12-1.65), and 1.66 (1.38-2.01), respectively (P for trend >0.001). These associations were apparent in the clinically relevant subgroup analyses. CONCLUSIONS - Elevated serum ferritin levels were independently associated with future development of MetS during the 5-year follow-up period.
机译：目的-血清铁蛋白升高与代谢综合征（MetS）的患病率有关。但是，尚无研究检查血清铁蛋白水平是否确实与MetS的预期发展有关。因此，我们进行了一项前瞻性研究，以评估基线血清铁蛋白水平对MetS发育的纵向影响。研究设计和方法-追踪了2005年参加医学健康检查计划的18,022名健康韩国男性的无Mets队列，直到2010年。根据国际糖尿病联盟特别工作组的联合临时声明对MetS进行了定义。流行病学和预防。进行了Cox比例风险模型。结果-在45,919.3人年的随访期间，2006年至2010年间发生了2,127例MetS事件。在对多个协变量进行校正后，将MetS事件的危险比（95％CI）比较了血清铁蛋白的第二个五分位数和第五个五分位数相对于前五分位数的水平分别为1.19（0.98-1.45），1.17（0.96-1.43），1.36（1.12-1.65）和1.66（1.38-2.01）（趋势> 0.001的P）。这些关联在临床相关的亚组分析中显而易见。结论–在5年的随访期内，血清铁蛋白水平的升高与MetS的未来发展独立相关。

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