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Metabolic and inflammatory links to depression in youth with diabetes

机译：代谢和炎性链接与青年糖尿病患者的抑郁症

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OBJECTIVE - Youth with diabetes are at increased risk for depression. The objectives of this study were to provide preliminary evidence that this at-risk status for depression is associated with metabolic and inflammatory markers and to inform future, more stringent examinations of the directionality of these associations. RESEARCH DESIGN AND METHODS - Data from SEARCH for Diabetes in Youth (SEARCH), an observational study of U.S. children diagnosed with diabetes at <20 years of age, were used for these analyses. SEARCH participants were drawn from four geographically defined populations in Ohio, Washington, South Carolina, and Colorado; health plan enrollees in Hawaii and California; and Indian Health Service beneficiaries from four Native American populations. Participants were 2,359 youth with diabetes from the 2001 prevalent and 2002-2004 incident SEARCH cohorts. Depression was measured with the Center for Epidemiologic Studies Depression scale. Eight metabolic and inflammatory markers were measured: adiponectin, leptin, C-reactive protein, serum amyloid A, apolipoprotein B (apoB), lipoprotein A, interleukin-6, and LDL. RESULTS - Six of eight markers were significantly (P < 0.006) associated with depression in youth with diabetes in bivariate analyses. In general, higher levels of depression were associated with indicators of worse metabolic or inflammatory functioning. In regression models stratified by diabetes type and accounting for demographic and clinical characteristics, only higher levels of apoB remained associated with higher levels of depression in youth with type 1 diabetes. CONCLUSIONS - These data suggest that depression reported by youth with diabetes is partially associated with metabolic abnormalities and systemic inflammation.
机译：目的-糖尿病青年患抑郁症的风险增加。这项研究的目的是提供初步的证据，表明这种处于抑郁状态的危险状态与代谢和炎性标志物有关，并为将来更严格地检查这些关联的方向提供信息。研究设计和方法-来自青少年糖尿病研究（SEARCH）的数据被用于这些分析，该研究是对美国儿童的诊断性研究，年龄小于20岁。搜索参与者来自俄亥俄州，华盛顿州，南卡罗来纳州和科罗拉多州的四个地理区域人群;夏威夷和加利福尼亚的健康计划参加者;以及来自四个美洲原住民人群的印度卫生服务受益人。参加者为2001年流行和2002-2004年SEARCH队列中的2359名糖尿病青年。用流行病学研究中心抑郁量表测量抑郁。测量了八个代谢和炎性标记：脂联素，瘦素，C反应蛋白，血清淀粉样蛋白A，载脂蛋白B（apoB），脂蛋白A，白介素6和LDL。结果-在双变量分析中，八个标记中有六个与糖尿病青年的抑郁症显着相关（P <0.006）。通常，较高的抑郁水平与不良的代谢或炎症功能相关。在按糖尿病类型分层并考虑人口统计学和临床​​特征的回归模型中，只有较高水平的apoB仍与1型糖尿病青年的较高抑郁水平相关。结论-这些数据表明，青年糖尿病患者报告的抑郁症与代谢异常和全身性炎症部分相关。

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