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首页> 外文期刊>Diabetes care >Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes among South Asian Surinamese, African Surinamese, and ethnic Dutch: The population-based SUNSET study
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Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes among South Asian Surinamese, African Surinamese, and ethnic Dutch: The population-based SUNSET study

机译：南亚苏里南，非洲苏里南和荷兰裔人群中2型糖尿病患者血清铁蛋白与空腹血糖之间的关联性别差异：基于人群的SUNSET研究

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OBJECTIVE-Moderately elevated iron stores below the levels commonly associated with hemochromatosis have been implicated in the etiology of diabetes. Studies suggest that iron status (measured by serum ferritin) differs significantly according to sex, but inconsistent findings have been reported. Our aim is to test the association between serum ferritin and the prevalence of type 2 diabetes and fasting glucose concentrations in a population-based, multiethnic, cross-sectional study including men and women of African Surinamese, South Asian Surinamese, and ethnic Dutch origin. RESEARCH DESIGN AND METHODS-We analyzed data on 508 ethnic Dutch, 597 African Surinamese, and 339 South Asian Surinamese aged 35-60 years. Type 2 diabetes was defined as a fasting plasma glucose level ??7.0 mmol/L or a self-reported diagnosis. RESULTS-Serum ferritin was positively associated with type 2 diabetes and fasting glucose, but differences in the associations according to sex were observed. Serum ferritin concentration was positively associatedwith type 2 diabetes among women in all ethnic groups (odds ratio [OR] ethnic Dutch: 1.07 [95% CI 1.01-1.13]; OR South Asian Surinamese: 1.05 [1.00-1.10]; OR African Surinamese: 1.05 [1.01-1.10]), but not among men. Serum ferritin was also more strongly associated with fasting glucose in women than in men. Moreover, the magnitude of sex differences in the association between serum ferritin and fasting glucose, but not type 2 diabetes, was more pronounced in the African Surinamese group than in the other ethnic groups (P for interaction ??0.0001). CONCLUSIONS-We found a positive association between serum ferritin and type 2 diabetes and fasting glucose in our multiethnic population, which appeared stronger among women than men. Further evaluation of the variation in sex differences between ethnic groups is warranted, particularly among the African Surinamese, to understand the mechanisms behind these sex differences. ? 2013 by the American Diabetes Association.
机译：目的-铁的储藏量适度升高到通常与血色素沉着病相关的水平以下已经与糖尿病的病因有关。研究表明，铁的状态（通过血清铁蛋白测定）因性别而有显着差异，但据报道不一致。我们的目标是在一项以人群为基础的多种族，横断面研究中，包括非洲苏里南，南亚苏里南和荷兰裔的男性和女性，测试血清铁蛋白与2型糖尿病患病率和空腹血糖浓度之间的关联。研究设计和方法-我们分析了年龄在35至60岁之间的508名荷兰人，597名非洲苏里南人和339名南亚苏里南人的数据。 2型糖尿病定义为空腹血糖≥7.0 mmol / L或自我报告的诊断。结果血清铁蛋白与2型糖尿病和空腹血糖呈正相关，但根据性别观察其相关性存在差异。所有族裔妇女的血清铁蛋白浓度与2型糖尿病呈正相关（荷兰人的比值比[OR]：1.07 [95％CI 1.01-1.13];或南亚苏里南语：1.05 [1.00-1.10];或非洲苏里南语： 1.05 [1.01-1.10]），但男性之间则不然。与男性相比，女性血清铁蛋白与空腹血糖的相关性也更高。此外，非洲苏里南组的血清铁蛋白与空腹血糖之间的关联，但不是2型糖尿病，性别差异的幅度比其他种族更为明显（相互作用的P≥0.0001）。结论-我们在多族裔人群中发现血清铁蛋白和2型糖尿病与空腹血糖之间呈正相关，其中女性比男性更强。有必要进一步评估族裔之间性别差异的变化，尤其是非洲苏里南人，以了解这些性别差异背后的机制。 ？ 2013年由美国糖尿病协会颁发。

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