...
首页> 外文期刊>Diabetes care >Type 2 diabetes: Etiology and reversibility
【24h】

Type 2 diabetes: Etiology and reversibility

机译:2型糖尿病:病因和可逆性

获取原文
获取原文并翻译 | 示例
           

摘要

Reversal of type 2 diabetes to normal metabolic control by either bariat-ric surgery or hypocaloric diet allows for the time sequence of underlying path-ophysiologic mechanisms to be observed. In reverse order, the same mechanisms are likely to determine the events leading to the onset of hyperglycemia and permit insight into the etiology of type 2 diabetes. Within 7 days of instituting a substantial negative calorie balance by either dietary intervention or bariatric surgery, fasting plasma glucose levels can normalize. This rapid change relates to a substantial fall in liver fat content and return of normal hepatic insulin sensitivity. Over 8 weeks, first phase and maximal rates of insulin secretion steadily return to normal, and this change is in step with steadily decreasing pancreatic fat content.
机译:通过减肥手术或低热量饮食将2型糖尿病逆转为正常的代谢控制,可以观察到潜在的病理生理机制的时间序列。相反,相同的机制很可能确定导致高血糖发作的事件,并允许洞悉2型糖尿病的病因。在通过饮食干预或减肥手术建立明显的负热量平衡后的7天内,空腹血糖水平可以恢复正常。这种快速变化与肝脏脂肪含量的大幅下降和正常肝胰岛素敏感性的恢复有关。在8周的时间里,胰岛素分泌的第一阶段和最大速率稳定地恢复正常,并且这种变化与胰腺脂肪含量的稳定下降是同步的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号