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首页> 外文期刊>Diabetes care >The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.
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The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.

机译：在1989年至2000年之间，比利时安特卫普（比利时）的0-39岁年龄组1型糖尿病的发病率并未增加：这是早期疾病表现的证据。

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摘要

OBJECTIVE: A worldwide increase in the incidence of childhood type 1 diabetes has been observed. Because in various countries the majority of new type 1 diabetic patients are diagnosed in adulthood, we investigated whether the rising incidence of this disorder in children reflects a global increase in the incidence of diabetes or a shift toward earlier clinical presentation. RESEARCH DESIGN AND METHODS: The incidence of type 1 diabetes presenting before age 40 years was prospectively measured in the Antwerp district over a 12-year period (1989-2000). The completeness of ascertainment was evaluated by the capture-recapture method. Trends in incidence during the study period were analyzed by Poisson regression. RESULTS: The incidence of type 1 diabetes diagnosed before age 40 years remained constant over the 12-year period, averaging 9.9 cases per 100,000 individuals per year. The incidence was similar in both sexes under age 15 years, but a marked male excess was noted for adult-onset disease, in particular after age 20 years, resulting in a male-to-female ratio of 0.9 under age 15 years vs. 1.6 thereafter (P = 0.001). During the 12-year observation period, there was a significant tendency toward increasing incidence under age 15 years at the expense of a decreasing incidence between ages 15 and 40 years (P = 0.025). The annual increase in incidence averaged 1.8% under age 15 years and 5.0% under age 5 years (P = 0.06). CONCLUSIONS: Our results indicate that in Belgium, the increasing incidence of childhood type 1 diabetes-especially for children under age 5 years-is not attributable to a global increase in disease incidence, but rather to earlier clinical manifestation. The results suggest that an environmental factor may preferentially accelerate the subclinical disease process in young diabetes-prone subjects.
机译：目的：观察到世界范围内儿童期1型糖尿病的发病率增加。因为在许多国家/地区，大多数新的1型糖尿病患者被诊断为成年，所以我们调查了这种疾病在儿童中的发病率上升是否反映了糖尿病发病率的全球上升或向早期临床表现的转变。研究设计与方法：前瞻性测量了安特卫普地区在12年期间（1989-2000年）出现的40岁以前的1型糖尿病的发病率。确定性的完整性通过捕获-再捕获方法进行评估。通过泊松回归分析研究期间的发病率趋势。结果：在40岁之前诊断出的1型糖尿病的发病率在12年期间保持恒定，每年每100,000个人平均9.9例。 15岁以下的男性和女性的发病率相似，但是成人发病尤其是20岁之后的男性明显过量，导致15岁以下的男女比例为0.9，而1.6岁为1.6之后（P = 0.001）。在12年的观察期内，有一个明显的趋势是15岁以下的发病率增加，而15岁到40岁之间的发病率却下降了（P = 0.025）。 15岁以下的年平均发病率平均增长1.8％，5岁以下的年平均发病率平均增长5.0％（P = 0.06）。结论：我们的研究结果表明，在比利时，儿童1型糖尿病的发病率增加，尤其是5岁以下儿童的发病率增加，并非归因于疾病发病率的整体上升，而是由于早期的临床表现。结果表明，环境因素可能会优先促进易患糖尿病的年轻受试者的亚临床疾病进程。

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