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首页> 外文期刊>Diabetes care >Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.
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Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.

机译：在肥胖的西方人群中，铬治疗对胰岛素治疗的2型糖尿病控制不佳的患者无效：一项随机，双盲，安慰剂对照的试验。

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OBJECTIVE: Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes. The aim of this study was to determine the effect of chromium treatment on glycemic control in a Western population of insulin-dependent patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: In this 6-month double-blind study, patients with an HbA(1c) (A1C) >8% and insulin requirements of >50 units/day were randomly assigned to receive treatment with placebo or 500 or 1,000 mug chromium daily in the form of chromium picolinate. The primary efficacy parameter was a change in A1C. Secondary end points were changes in lipid profile, BMI, blood pressure, and insulin requirements. RESULTS: In this per-protocol analysis (n = 46), the decrease in A1C was approximately equal across the three groups (0.4%). All patients had a BMI >25 kg/m(2). No differences were found in the secondary end points. We found a weak relationship between an increasing serum chromium concentration and improvement of the lipid profile. CONCLUSIONS: There is no evidence that high-dose chromium treatment is effective in obese Western patients with type 2 diabetes.
机译：目的：据报道铬治疗可改善2型糖尿病患者特定人群的血糖控制和胰岛素敏感性。这项研究的目的是确定铬治疗对胰岛素依赖型2型糖尿病患者的西方人群血糖控制的影响。研究设计和方法：在为期6个月的双盲研究中，HbA（1c）（A1C）> 8％且胰岛素需求量> 50单位/天的患者被随机分配接受安慰剂或500或1,000杯的治疗铬以吡啶甲酸铬形式存在。主要功效参数是A1C的变化。次要终点是脂质分布，BMI，血压和胰岛素需求量的变化。结果：在此基于方案的分析中（n = 46），三组中的A1C下降大致相等（0.4％）。所有患者的BMI> 25 kg / m（2）。在次级终点没有发现差异。我们发现血清铬浓度增加与脂质分布改善之间存在弱关联。结论：没有证据表明高剂量铬治疗对肥胖的西方2型糖尿病患者有效。

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