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首页> 外文期刊>Diabetes care >Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis.
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Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis.

机译：丙氨酸氨基转移酶，γ-谷氨酰转移酶和糖尿病：英国妇女的心脏与健康研究和荟萃分析。

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OBJECTIVE: To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS: ALT and GGT were studied as determinants of diabetes in the British Women's Heart and Health Study, a cohort of 4,286 women 60-79 years old (median follow-up 7.3 years). A systematic review and a meta-analysis of 21 prospective, population-based studies of ultrasonography, which diagnosed nonalcoholic fatty liver disease (NAFLD), ALT, and GGT as determinants of diabetes, were conducted, and associations of ALT and GGT with diabetes were compared. RESULTS: Ultrasonography-diagnosed NAFLD was associated with more than a doubling in the risk of incident diabetes (three studies). ALT and GGT both predicted diabetes. The fully adjusted hazard ratio (HR) for diabetes per increase in one unit of logged ALT was 1.83 (95% CI 1.57-2.14, I(2) = 8%) and for GGT was 1.92 (1.66-2.21, I(2) = 55%). To directly compare ALT and GGT as determinants of diabetes, the fully adjusted risk of diabetes in the top versus bottom fourth of the ALT and GGT distributions was estimated using data from studies that included results for both markers. For ALT, the HR was 2.02 (1.59-2.58, I(2) = 27%), and for GGT the HR was 2.94 (1.98-3.88, I(2) = 20%), suggesting that GGT may be a better predictor (P = 0.05). CONCLUSIONS: Findings are consistent with the role of liver fat in diabetes pathogenesis. GGT may be a better diabetes predictor than ALT, but additional studies with directly determined liver fat content, ALT, and GGT are needed to confirm this finding.
机译：目的：评估和比较丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）与糖尿病的相关性。研究设计和方法：在英国女性心脏与健康研究中，ALT和GGT作为糖尿病的决定因素进行了研究，该研究队列了4286名60-79岁的妇女（中位随访时间为7.3年）。对21项基于人群的前瞻性超声研究进行了系统的综述和荟萃分析，这些研究诊断出非酒精性脂肪性肝病（NAFLD），ALT和GGT是糖尿病的决定因素，并且将ALT和GGT与糖尿病相关联比较。结果：超声诊断的NAFLD与发生糖尿病的风险增加了一倍以上有关（三项研究）。 ALT和GGT均可预测糖尿病。糖尿病每升高一个单位记录的ALT，其完全调整的危险比（HR）为1.83（95％CI 1.57-2.14，I（2）= 8％），GGT的完全危险度为1.92（1.66-2.21，I（2） = 55％）。为了直接比较ALT和GGT作为糖尿病的决定因素，使用包括这两种标记物结果的研究数据估算了ALT和GGT分布的顶部和底部四分之一的完全调整的糖尿病风险。对于ALT，HR为2.02（1.59-2.58，I（2）= 27％），对于GGT，HR为2.94（1.98-3.88，I（2）= 20％），这表明GGT可能是更好的预测指标（P = 0.05）。结论：研究结果与肝脂肪在糖尿病发病机制中的作用一致。与ALT相比，GGT可能是更好的糖尿病预测指标，但是需要直接确定肝脂肪含量，ALT和GGT的其他研究来证实这一发现。

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