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首页> 外文期刊>Diabetes care >Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men.
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Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men.

机译:从1984年至2007年BMI上升趋势可以解释最近2型糖尿病发病率的上升吗?:来自英国男性前瞻性研究的证据。

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OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007. RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up. RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase. CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.
机译:目的:估计1984年至2007年英国男性BMI升高的程度可以解释2型糖尿病发病率的上升。研究设计与方法:对6,460名英国男性的代表性队列研究进行了随访1984年(45-65岁)和2007年(67-89岁)。在随访之前和期间定期检查BMI。结果:在1984-1992年至1999-2007年间,按年龄调整的2型糖尿病风险增加了一倍以上(风险比2.33 [95%CI 1.75-3.10])。在1984年至1999年之间,平均BMI上升了1.42 kg / m(2)(95%CI 1.10-1.74);这可以解释26%(95%CI 17-38)的2型糖尿病增加。结论:2型糖尿病的明显增加可归因于BMI的变化。很大一部分仍无法解释,可能与其他决定因素(例如体育活动)有关。这值得进一步研究。

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