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首页> 外文期刊>Diabetes research and clinical practice >Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.
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Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.

机译：血清胆红素与高敏感度C反应蛋白，糖化血红蛋白和2型糖尿病在日本中老年男女中的患病率呈负相关。

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摘要

AIM: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400). METHODS: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA(1c) and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. RESULTS: Geometric means of hs-CRP and HbA(1c) were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA(1c) was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P=0.0004 in men and trend P=10(-5) in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P=0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P=0.01), with adjustment for hs-CRP. CONCLUSIONS: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.
机译：目的：本研究的目的是检查血清胆红素（一种内源性抗氧化剂）与血清高敏C反应蛋白（hs-CRP）水平，HbA（1c）的相关性，以及中度2型糖尿病的患病率日本男女老人（n = 12,400）。方法：采用协方差分析和logistic回归分析分别根据胆红素浓度估算hs-CRP和HbA（1c）的几何平均值以及流行糖尿病的比值比，并对行为因素和肝酶进行统计学调整。结果：随着男女血清胆红素浓度的增加，hs-CRP和HbA（1c）的几何平均值逐渐降低。调整hs-CRP后，血清胆红素和HbA（1c）之间的负相关性略有减弱，但仍然非常显着（男性趋势P = 0.0004，女性趋势P = 10（-5））。血清总胆红素最低至最高五分位数的普遍糖尿病多因素校正比值比为1.00、1.00、0.73、0.80和0.73（趋势P = 0.002），而未调整hs-CRP和1.00、1.04、0.76， 0.86和0.79（趋势P = 0.01），并调整了hs-CRP。结论：较高浓度的血清胆红素可能对2型糖尿病的发展具有保护作用。

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