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首页> 外文期刊>Diabetes research and clinical practice >Potential celiac disease in type 1 diabetes: a multicenter study.
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Potential celiac disease in type 1 diabetes: a multicenter study.

机译：1型糖尿病的潜在腹腔疾病：一项多中心研究。

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摘要

AIMS: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. METHODS: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. RESULTS: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n=77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n=114; p=0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. CONCLUSIONS: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.
机译：目的：描述1型糖尿病（T1DM）年轻患者中潜在腹腔疾病（pot-CD）的患病率，并描述其临床特征。方法：这项横断面多中心研究纳入了来自31个意大利中心的8717名T1DM患者。收集了有关T1DM患者，CD患者和pot-CD患者总数的信息。收集了以下有关CD盆栽患者的数据：性别，T1DM诊断时的年龄，首次CD血清学阳性时的年龄，CD相关症状的存在，其他自身免疫性疾病的存在以及无麸质饮食（GFD）的治疗。对照组为CD血清学阳性的131例患者。结果：7.2％的T1DM患者发现CD血清学阳性。在CD阳性患者中，pot-CD的患病率为12.2％（n = 77）：症状出现在12/77。在15名患者中发现了第三种自身免疫性疾病。对照人群中pot-CD的患病率为8.4％（n = 114; p = 0.005）。在临床特征方面未发现差异。 T1DM和对照患者中仅有少数有症状的患者接受GFD治疗。结论：尽管不能排除遗传因素的影响，在T1DM患者中发现pot-CD的患病率较高，这可能归因于常规筛查。

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