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首页> 外文期刊>Diabetes research and clinical practice >The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance.
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The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance.

机译：血脂异常对芬兰人和瑞典人不同类别的糖耐量对冠心病发病率的影响。

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BACKGROUND: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. METHODS: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated. RESULTS: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG. CONCLUSION: Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia.
机译：背景：血脂异常与冠心病（CHD）发病率的关系尚未在具有不同血糖类别的人群中进行深入研究。方法：对来自芬兰和瑞典的六项基于人群的前瞻性研究的数据进行了分析，其中年龄在25-89岁之间的4818名男性和4269名女性无冠心病且基线时无糖尿病史。估计了冠心病发病率的多元调整风险比（HRs）和95％置信区间（CIs）。结果：457名参与者在10年的随访期间患了冠心病。冠心病发病率的多元调整后HR（95％CI）为1.39（1.08-1.80），0.57（0.39-0.84），1.21（1.07-1.37），1.56（1.21-2.01）和1.74（1.34-2.26），对应于新诊断糖尿病患者的总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），甘油三酸酯（TG），非HDL-C和TC与HDL比率的Z分数增加一个单位。该预测在非糖尿病人群中也很重要，除了正常血糖患者的TG和孤立IFG患者的TG和HDL-C。结论：在正常血糖，空腹高血糖和糖尿病患者中，不良的脂质状况与冠心病的发生率增加有关，而与IGT患者无关。该发现可能意味着对空腹或负荷后高血糖症患者考虑不同的治疗策略。

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