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首页> 外文期刊>Zeitschrift fur Kristallographie. Crystalline Materials >Association of combined features of amino acid and protein with crystallization propensity of proteins from Cytophaga Hutchinsonii
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Association of combined features of amino acid and protein with crystallization propensity of proteins from Cytophaga Hutchinsonii

机译：氨基酸和蛋白质结合特征与细胞吞噬细胞蛋白结晶倾向的关系

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摘要

Various features of amino acids have been so far associated with crystallization propensity of proteins. The majority of features generally represents a certain aspect of individual amino acid, for example, molecular weight of an amino acid. Meanwhile, a small portion of features, which represents a certain aspect of a whole protein, is also associated with crystallization propensity of proteins, such as protein length. Clearly, the features of individual amino acids distinguish themselves from the features of a whole protein. Therefore it would be more rationale to use the features, which combine both features of individual amino acids and a whole protein, to associate crystallization propensity of proteins, because the features of individual amino acids are not subject to amino acids' positions in a protein, for instance. In this study, each of three combined features of individual amino acids and a whole protein are associated with crystallization propensity of proteins from Cytophaga Hutchin sonii through logistic regression and neural network, and each of 535 features of individual amino acids is also associated with crystallization propensity of the proteins to serve as benchmark. The results show that the combined features have a good relationship with crystallization propensity of proteins from Cytophaga Hutchinsonii. This study provides the information that the combined features can be used for predicting crystallization propensity of protein.
机译：迄今为止，氨基酸的各种特征与蛋白质的结晶倾向有关。大多数特征通常代表单个氨基酸的某个方面，例如氨基酸的分子量。同时，代表整个蛋白质的某个方面的一小部分特征也与蛋白质的结晶倾向（例如蛋白质长度）相关。显然，单个氨基酸的特征使其与整个蛋白质的特征区分开。因此，将各个氨基酸和整个蛋白质的特征相结合的特征与蛋白质的结晶倾向结合起来是更合理的，因为各个氨基酸的特征不受蛋白质中氨基酸的位置的影响，例如。在这项研究中，通过逻辑回归和神经网络，单个氨基酸和一个完整蛋白的三个组合特征中的每一个都与细胞噬菌体蛋白质的结晶倾向相关，并且单个氨基酸的535个特征中的每一个也都与结晶倾向相关。蛋白质作为基准。结果表明，结合的特征与细胞吞噬细胞蛋白的结晶倾向具有良好的关系。这项研究提供的信息是，结合的特征可用于预测蛋白质的结晶倾向。

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