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首页> 外文期刊>Diagnostic cytopathology >Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration
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Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration

机译：细针穿刺模仿肺鳞状细胞癌的转移性增生性乳腺癌

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Metaplastic squamous cell carcinoma (SCC) of the breast is a rare type of breast cancer. Metastases to the lung, which can be a major site of second primary tumor development among breast cancer patients, are difficult to distinguish from primary SCC of the lung and present a unique challenge for pathologists. There are few available discriminating immunohistochemical markers as squamous differentiation typically leads to loss of expression of characteristic primary epithelial cell markers of both breast and lung origin. GATA protein binding 3 (GATA-3) is a useful marker of breast origin in metastatic ductal and lobular carcinomas including poorly differentiated triple-negative carcinomas and some metaplastic carcinomas. Here, we present a case of metastatic SCC presenting as a solitary lung mass with regional lymph node metastases and a single satellite lesion in a patient with a history of metaplastic SCC of the breast. In addition to the routine markers of squamous differentiation, the metastases were also positive for estrogen receptor (ER) and GATA-3 on cytologic material obtained by transbronchial FNA. This suggests that immunoreactivity for ER and GATA-3 may support a diagnosis of metastatic SCC in the context of a prior metaplastic SCC of the breast. Diagn. Cytopathol. 2015;43:844-849. (c) 2015 Wiley Periodicals, Inc.
机译：乳房的化生性鳞状细胞癌（SCC）是一种罕见的乳腺癌。肺转移可能是乳腺癌患者继发原发性肿瘤的主要部位，很难与原发性肺鳞癌区分开来，这给病理学家带来了独特的挑战。几乎没有可用的区分免疫组织化学标记物，因为鳞状分化通常会导致乳腺和肺来源的特征性原发性上皮细胞标记物的表达丧失。 GATA蛋白结合3（GATA-3）是转移性导管和小叶癌（包括分化较差的三阴性癌和某些化生癌）中乳腺癌起源的有用标志物。在这里，我们介绍了一个转移性SCC病例，表现为孤立性肺肿块，伴有区域性淋巴结转移和单发卫星病变，该病患者患有乳腺上皮化生性SCC。除鳞状细胞分化的常规标记外，转移经支气管FNA获得的细胞学材料上的雌激素受体（ER）和GATA-3阳性。这表明对于ER和GATA-3的免疫反应性可能支持在先前的乳腺化生性SCC的情况下诊断转移性SCC。诊断细胞病。 2015; 43：844-849。 （c）2015年威利期刊有限公司

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