• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diagnostic cytopathology >Fine Needle Aspiration Cytology of Histiocytic Sarcoma With Dendritic Cell Differentiation: A Case of Transdifferentiation From Low-Grade Follicular Lymphoma
【24h】

Fine Needle Aspiration Cytology of Histiocytic Sarcoma With Dendritic Cell Differentiation: A Case of Transdifferentiation From Low-Grade Follicular Lymphoma

机译：具有树突状细胞分化的组织细胞肉瘤的细针穿刺细胞学：一例低级滤泡性淋巴瘤转分化的病例。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Histiocytic sarcoma (HS) is a rare malignant tumor, and in extraordinary circumstances it can be transdifferentiated from a low-grade B-cell lymphoma. In our report, a 62-year-old female was initially diagnosed with a low-grade follicular lymphoma, and 2 years later she presented with bilateral lung masses and lymphadenopathy. Fine needle aspiration (FNA) of the lung masses revealed solid nests of large pleomorphic epithelioid cells. By immunohistochemical studies, the tumor cells were positive for histiocytic markers (CD68 and CD163) and S100, supporting a diagnosis of HS with dendritic cell differentiation. Further fluorescence in situ hybridization (FISH) analyses detected IGH@/BCL2 rearrangement in both the previous follicular lymphoma and the current HS, which was highly suggestive of the clonal relationship between these two tumors. To the best of our knowledge, this is the first case of transformation of follicular lymphoma into HS diagnosed by FNA of lung masses. (C) 2015 Wiley Periodicals, Inc.
机译：组织细胞肉瘤（HS）是一种罕见的恶性肿瘤，在特殊情况下可以从低度B细胞淋巴瘤转分化。在我们的报告中，一位62岁的女性最初被诊断为低度滤泡性淋巴瘤，两年后她出现了双侧肺部肿块和淋巴结病。肺部肿块的细针穿刺（FNA）显示了大的多形上皮样细胞的固体巢。通过免疫组织化学研究，肿瘤细胞的组织细胞标记物（CD68和CD163）和S100呈阳性，支持诊断具有树突状细胞分化的HS。进一步的荧光原位杂交（FISH）分析在先前的滤泡性淋巴瘤和当前的HS中检测到了IGH @ / BCL2重排，这强烈暗示了这两种肿瘤之间的克隆关系。据我们所知，这是第一例由肺部肿块FNA诊断为滤泡性淋巴瘤转化为HS的病例。 （C）2015威利期刊公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号