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首页> 外文期刊>Diagnostic cytopathology >A Case Report of Urothelial Carcinoma With Combined Micropapillary and Plasmacytoid Morphology in the Urinary Bladder
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A Case Report of Urothelial Carcinoma With Combined Micropapillary and Plasmacytoid Morphology in the Urinary Bladder

机译：尿囊癌合并微乳头和浆细胞样形态的尿路上皮癌1例报告

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A case of combined micropapillary and plasmacytoid urothelial carcinoma (UC) of the urinary bladder is presented for a 74-year-old male who was admitted to the hospital with gross hematuria and multifocal papillary bladder tumors. Abdominal computed tomography showed a large enhancing mass on the left lateral and anterior wall of the urinary bladder, which was highly suspicious for extravesicular extension and focal extension of the anterior lesion to the pubic bone. In voided urine, cancer cells were scattered as micropapillae or nests as well as single cells on the low power view. On a higher power view, micropapillae or nests were composed of pleomorphic, high grade tumor cells with an inverted nuclear arrangement and with acinar structures occasionally identified. Single cells were discohesive and large with a thick cytoplasm and eccentrically located nuclei. Histologically, the tumor from the resected bladder showed diffusely infiltrating micropapillae or nests with a surrounding halo and dense singly-scattered plasmacytoid cells. Immunohistochemically, the cancer cells were positive for cytokeratin-7 and cytokeratin-20 but negative for S-100, leukocyte common antigen, and vimentin. At the time of radical cystectomy, severe adhesions and peritoneal metastases were found and the surgery was discontinued. The patient received systemic chemotherapy, but died of bladder cancer 14 months after surgery. (C) 2015 Wiley Periodicals, Inc.
机译：一名74岁男性因肉眼血尿和多灶性乳头状膀胱肿瘤入院，出现一例合并膀胱微乳头和浆细胞样尿路上皮癌（UC）的病例。腹部计算机断层扫描显示在膀胱左外侧和前壁有较大的肿块，这对于前病变至耻骨的囊外扩展和局灶性扩展高度怀疑。在排尿中，癌细胞在低倍视野中散布为微乳头或巢状以及单个细胞。从更高的角度来看，微乳头或巢由多形，高级别的肿瘤细胞组成，它们具有倒置的核排列并偶有腺泡结构。单细胞多毛，胞质厚，胞核偏心。在组织学上，来自切除膀胱的肿瘤表现为弥漫性浸润的微乳头或巢，周围有光环和密集的单分散浆细胞样细胞。免疫组织化学分析，癌细胞对细胞角蛋白7和细胞角蛋白20呈阳性，但对S-100，白细胞共同抗原和波形蛋白呈阴性。在进行根治性膀胱切除术时，发现严重的粘连和腹膜转移，并且中止了手术。该患者接受了全身化学疗法，但在手术后14个月死于膀胱癌。 （C）2015威利期刊公司

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