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首页> 外文期刊>Diagnostic microbiology and infectious disease >Performance in detection and reporting beta-lactam resistance phenotypes in Enterobacteriaceae: a nationwide proficiency study in Italian laboratories.
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Performance in detection and reporting beta-lactam resistance phenotypes in Enterobacteriaceae: a nationwide proficiency study in Italian laboratories.

机译：在肠杆菌科细菌中检测和报告β-内酰胺抗性表型的性能：意大利实验室的一项全国性能力研究。

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摘要

We evaluated the ability of 60 Italian clinical microbiology laboratories in detecting and reporting beta-lactam resistance phenotypes in Enterobacteriaceae. Laboratories received 5 well-characterized isolates producing extended-spectrum beta-lactamases (ESBLs), 2 hyperproducers of chromosomal enzymes, and 3 quality control strains. The performances in antimicrobial susceptibility testing (AST) were different depending on the species and type of ESBL produced. High rates of very major errors (up to 56%) were observed for ESBL producers when testing cephalosporins and aztreonam, especially in the case of CTX-M-1-producing Escherichia coli and TEM-52-producing Proteus mirabilis. Isolates hyperproducing chromosomal enzymes were erroneously reported as ESBL producers in approximately 20% of cases. Detection of ESBLs is still a problem for clinical microbiology laboratories. Overall, performances in AST appear to be better with Klebsiella spp. producing well-known enzymes (e.g., SHV type) than with strains producing emerging enzymes (e.g., CTX-M type) or organisms not well recognized as ESBL producers (e.g., P. mirabilis).
机译：我们评估了意大利60家临床微生物学实验室检测和报告肠杆菌科细菌中β-内酰胺耐药表型的能力。实验室收到了5个特征明确的分离株，它们产生了广谱的β-内酰胺酶（ESBLs），2个染色体酶高产菌和3个质量控制菌株。根据生产的ESBL的种类和类型，抗微生物药敏试验（AST）的性能有所不同。在测试头孢菌素和氨曲南时，特别是在产生CTX-M-1的大肠杆菌和产生TEM-52的变形杆菌（Proteus mirabilis）的情况下，ESBL生产者观察到很高的非常重大的错误率（高达56％）。在大约20％的情况下，错误地将分离的高产染色体酶报告为ESBL生产者。对于临床微生物学实验室来说，ESBLs的检测仍然是一个问题。总体而言，使用克雷伯菌属后，AST的性能似乎更好。与产生新兴酶的菌株（例如CTX-M型）或未被很好地识别为ESBL产生者的生物（例如，奇异毕赤酵母）相比，产生众所周知的酶（例如，SHV型）的菌株更为容易。

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