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首页> 外文期刊>Diagnostic microbiology and infectious disease >Risk factors for hospital-acquired pneumonia caused by carbapenem-resistant Gram-negative bacteria in critically ill patients: a multicenter study in Korea.
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Risk factors for hospital-acquired pneumonia caused by carbapenem-resistant Gram-negative bacteria in critically ill patients: a multicenter study in Korea.

机译：重症患者对碳青霉烯耐药的革兰氏阴性菌引起的医院获得性肺炎的危险因素：韩国的一项多中心研究。

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摘要

We performed a case-control study to identify risk factors of carbapenem-resistant Gram-negative bacteria (CRGNB) as an increasing cause of hospital-acquired pneumonia (HAP). The study included critically ill adult patients with HAP whose microbial etiology was identified at eight tertiary centers in Korea between June 2008 and December 2009. Eighty two patients with 86 isolates of CRGNB (62 Acinetobacter baumannii, 14 Pseudomonas aeruginosa, and 10 Stenotrophomonas maltophilia) were included in the case group, and 122 patients with carbapenem-susceptible Gram-negative bacteria were included in the control group. Diabetes mellitus (adjusted odds ratio [aOR] 2.82, 95% confidence interval [95% CI] 1.25-6.38), radiologic score ≥5 (aOR 4.56, 95% CI 2.36-8.81), prior fluoroquinolone (aOR 2.39. 95% CI = 1.07-5.35), or carbapenem usage (aOR 2.82, 95% CI 1.75-17.83) were found to be independent risk factors. Fluoroquinolone and carbapenem should be cautiously used to avoid HAP caused by CRGNB.
机译：我们进行了一项病例对照研究，以确定对碳青霉烯耐药的革兰氏阴性细菌（CRGNB）的危险因素是医院获得性肺炎（HAP）的增加原因。该研究包括2008年6月至2009年12月在韩国的8个三级医疗中心发现的微生物病因的重症成人HAP。82例患者接受了86株CRGNB分离株（62例鲍曼不动杆菌，14例铜绿假单胞菌和10例嗜麦芽嗜单胞菌）。病例组包括122例碳青霉烯敏感性革兰氏阴性细菌患者。糖尿病（校正比值比[aOR] 2.82，95％置信区间[95％CI] 1.25-6.38），放射学评分≥5（aOR 4.56，95％CI 2.36-8.81），先前的氟喹诺酮（aOR 2.39。95％CI = 1.07-5.35）或碳青霉烯的使用（aOR 2.82，95％CI 1.75-17.83）是独立的危险因素。应谨慎使用氟喹诺酮和碳青霉烯类，以避免由CRGNB引起的HAP。

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