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首页> 外文期刊>Die Pharmazie >Differential pulse polarographic investigation of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole using a dropping mercury electrode
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Differential pulse polarographic investigation of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole using a dropping mercury electrode

机译：使用滴汞电极对抗真菌药伊曲康唑，酮康唑，氟康唑和伏立康唑进行微分脉冲极谱研究

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摘要

The electrochemical reactions of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole have been investigated by differential pulse polarography (DPP) using a dropping mercury electrode (DME). All investigations were carried out in Britton-Robinson buffer solutions and methanol with varying pH values. Ketoconazole and itraconazole both showed a reduction peak with a potential between -1.5V and -1.6 V. Stable and reproducible conditions for the determination of itraconazole (c = 1 × 10-7 M) were found within the pH range of 6.0 to 8.0 and for the determination of ketoconazole (c = 5 × 10-8 M) within pH 6.0 to 7.0. Voriconazole showed a reduction peak with a peak potential of -1.7 V (c = 1 × 10-5 M) within the pH range of 8.0 to 10.0. In the case of fluconazole no electrochemical activity was found.
机译：抗真菌药物伊曲康唑，酮康唑，氟康唑和伏立康唑的电化学反应已通过使用滴汞电极（DME）的差分脉冲极谱法（DPP）进行了研究。所有研究都是在Britton-Robinson缓冲溶液和pH值不同的甲醇中进行的。酮康唑和伊曲康唑均显示出一个还原峰，电位在-1.5V至-1.6 V之间。测定伊曲康唑的稳定和重现条件（c = 1×10-7 M）在6.0至8.0的pH范围内。用于在pH 6.0至7.0范围内测定酮康唑（c = 5×10-8 M）。在8.0至10.0的pH范围内，伏立康唑显示出一个还原峰，峰电位为-1.7 V（c = 1×10-5 M）。在氟康唑的情况下，未发现电化学活性。

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