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首页> 外文期刊>Turkish journal of biology >Noncoding RNAs and cancer
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Noncoding RNAs and cancer

机译：非编码RNA与癌症

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New and diverse groups of noncoding RNAs are beginning to be discovered. These noncoding RNAs are grouped based on their sizes, genomic positions, or distinctive functions ranging from the regulation of chromatin structure and gene expression to genome stability maintenance. Among noncoding RNAs, microRNAs are the best studied and understood small RNAs with direct and indirect roles in normal and in cancer cells. Given the high rate of transcription from noncoding parts of the genome, other noncoding elements are also of great interest. It is also of interest to understand that there may be interesting cases of crosstalk and/ or coregulation between the noncoding and the coding portion of the genome. Therefore, deregulated expression of noncoding RNAs can be considered to cause significant alterations in cancer cells. The complexities of the genome and transcriptome still remain mesmerizing. As we better understand these complexities, we will be able to improve our understanding of human conditions and will hopefully develop tools to improve the ways in which we deal with diseases, particularly cancer. Here, based on recent findings, we provide a descriptive profile of noncoding RNA classes, their roles, and their potential contributions to the complex events of tumorigenesis.
机译：开始发现新的和多样化的非编码RNA组。这些非编码RNA根据其大小，基因组位置或独特功能（从染色质结构和基因表达的调控到基因组稳定性的维持）进行分组。在非编码RNA中，对microRNA的研究最为透彻，最能理解的是在正常细胞和癌细胞中具有直接和间接作用的小RNA。考虑到来自基因组非编码部分的高转录率，其他非编码元件也引起了极大的兴趣。还有趣的是要理解，在基因组的非编码部分和编码部分之间可能存在有趣的串扰和/或共调节的情况。因此，可以认为非编码RNA的表达失调会导致癌细胞发生重大变化。基因组和转录组的复杂性仍然令人着迷。随着我们更好地了解这些复杂性，我们将能够增进对人类状况的了解，并有望开发工具来改善我们应对疾病（尤其是癌症）的方式。在这里，基于最新发现，我们提供了非编码RNA类的描述性概况，它们的作用以及它们对肿瘤发生复杂事件的潜在贡献。

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