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首页> 外文期刊>Diseases of Aquatic Organisms >Virological, serological and histopathological evaluation of fishstrain susceptibility to experimental infection with salmonidalphavirus
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Virological, serological and histopathological evaluation of fishstrain susceptibility to experimental infection with salmonidalphavirus

机译：病毒株对鲑鱼α病毒实验感染易感性的病毒学，血清学和组织病理学评估

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Pancreas disease (PD) of farmed Atlantic salmon Salmo salar L., which is caused by an alphavirus known as salmon pancreas disease virus (SPDV), can have serious economic consequences. An epidemiological survey carried out in Ireland in 2003 indicated that within individual farms there were significant differences in the susceptibility of different strains of farmed Atlantic salmon to infection with SPDV, as measured by levels of clinical disease and mortality. The aim of this preliminary study was to investigate this field observation by comparing lesion development, viraemia and serological responses of 3 commercial strains of Atlantic salmon (A, B and C) experimentally infected with SPDV. Highly significant differences in the severity of lesions in the pancreas at Day 21 post-infection (pi) were detected (p < 0.01), with Group B being more severely affected. There were also significant differences in the prevalence and severity of lesions in heart and skeletal muscle at Day 21 and 35 pi respectively, with Group B results again significantly higher than those from both Groups A and C (p < 0.05). There was no overlap between viraemia and the presence of specific SPDV antibody. Some fish in all groups had no viraemia, lesions or evidence of seroconversion. There were no significant differences seen between the challenged groups in relation to the percentage of viraemic fish at each time point. Viral loads were not determined. Differences between the number of antibody-positive fish in each challenge group were found at Days 28 and 35 pi (p < 0.1). Highly significant differences (p < 0.01) in the geometric mean titres of seropositive fish were detected at Day 28. These results, obtained using a challenge model, confirm that there are strain differences in the susceptibility to experimental SPDV infection in commercial farmed Atlantic salmon.
机译：养殖的大西洋鲑鱼Salmo salar L.的胰腺疾病（PD）由称为鲑鱼胰腺疾病病毒（SPDV）的甲型病毒引起，可能会造成严重的经济后果。 2003年在爱尔兰进行的一项流行病学调查表明，根据临床疾病和死亡率的水平，在各个养殖场中，养殖的大西洋鲑鱼不同菌株对SPDV感染的敏感性差异很大。这项初步研究的目的是通过比较实验性感染SPDV的3种大西洋鲑（A，B和C）商业菌株的病变发展，病毒血症和血清学应答，来调查这一现场观察。在感染后第21天（pi），检测到胰腺病变严重程度的高度显着差异（p <0.01），其中B组受到的影响更为严重。分别在第21天和第35天，心脏和骨骼肌病变的发生率和严重程度也存在显着差异，B组的结果再次明显高于A和C组（p <0.05）。病毒血症和特定SPDV抗体的存在之间没有重叠。所有组中的一些鱼类均无病毒血症，病灶或血清转化的迹象。在每个时间点，挑战组之间在病毒鱼的百分比方面没有发现显着差异。没有确定病毒载量。在感染后第28天和第35天发现每个攻击组的抗体阳性鱼的数量之间存在差异（p <0.1）。在第28天检测到血清阳性鱼的几何平均滴度存在极显着差异（p <0.01）。使用挑战模型获得的这些结果证实，在商业化养殖的大西洋鲑鱼中，对实验SPDV感染的敏感性存在菌株差异。

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