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首页> 外文期刊>Diseases of Aquatic Organisms >Protection against white spot syndrome virus (WSSV) infection in kuruma shrimp orally vaccinated with WSSV rVP26 and rVP28.
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Protection against white spot syndrome virus (WSSV) infection in kuruma shrimp orally vaccinated with WSSV rVP26 and rVP28.

机译：在口服WSSV rVP26和rVP28的黑熊虾中预防白斑综合症病毒（WSSV）感染。

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摘要

White spot syndrome virus (WSSV) is the causative agent of white spot disease (WSD), one of the most serious diseases affecting global shrimp farming. We compared WSSV infection induction in kuruma shrimp Marsupenaeus japonicus by oral, immersion, and intramuscular injection (IM) exposure methods and evaluated the oral vaccine prepared from the recombinant WSSV proteins rVP26 and rVP28. The 50% lethal doses (LD50) of WSSV by oral, immersion, and IM challenges were 10-0.4, 10-4.4, and 10-7.7 g shrimp-1, respectively, indicating that WSSV infection efficiency by oral challenge was significantly less than the other 2 challenge routes. However, in shrimp farms it is believed that WSSV infection is easily and commonly established by the oral route as a result of cannibalization of WSSV-infected shrimp. Kuruma shrimp vaccinated orally with WSSV rVP26 or rVP28 were challenged with WSSV by oral, immersion, and IM routes to compare protection efficacy. The relative percent survival values were 100% for oral challenge, 70 to 71% for immersion, and 34 to 61% for IM. Thus, the protection against WSSV-infection that was induced in kuruma shrimp by oral vaccination with rVP26 or rVP28 seemed equivalent to that obtained through IM vaccination.
机译：白斑综合症病毒（WSSV）是白斑病（WSD）的病原体，白斑病是影响全球虾类养殖的最严重疾病之一。我们通过口服，浸入和肌内注射（IM）暴露方法比较了黑头虾（Marsupenaeus japonicus）的WSSV感染诱导，并评估了由重组WSSV蛋白rVP26和rVP28制备的口服疫苗。口服，浸入和IM攻击对WSSV的50％致死剂量（LD 50 ）为10 -0.4 ，10 -4.4 和10 -7.7 g虾 -1 ，表明口服攻毒对WSSV的感染效率明显低于其他两种攻毒途径。然而，据信在养虾场中，由于被WSSV感染的虾食人化，容易通过口服途径建立WSSV感染。 WSSV通过口服，浸入和IM途径对经WSSV rVP26或rVP28口服接种的Kuruma虾进行攻击，以比较保护效果。口服攻击的相对生存百分比值为100％，浸入的生存率为70％至71％，IM的生存率为34％至61％。因此，通过用rVP26或rVP28口服疫苗在黑熊虾中诱导的针对WSSV感染的保护似乎与通过IM疫苗获得的保护相同。

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