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首页> 外文期刊>Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus >Progression of diffuse esophageal spasm to achalasia: Incidence and predictive factors
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Progression of diffuse esophageal spasm to achalasia: Incidence and predictive factors

机译：食管弥漫性食管痉挛进展为门失弛缓：发病率和预测因素

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摘要

The progression of certain primary esophageal motor disorders to achalasia has been documented; however, the true incidence of this decay is still elusive. This study aims to evaluate: (i) the incidence of the progression of diffuse esophageal spasm to achalasia, and (ii) predictive factors to this progression. Thirty-five patients (mean age 53 years, 80% females) with a manometric picture of diffuse esophageal spasm were followed for at least 1 year. Patients with gastroesophageal reflux disease confirmed by pH monitoring or systemic diseases that may affect esophageal motility were excluded. Esophageal manometry was repeated in all patients. Five (14%) of the patients progressed to achalasia at a mean follow-up of 2.1 (range 1-4) years. Demographic characteristics were not predictive of transition to achalasia, while dysphagia (P= 0.005) as the main symptom and the wave amplitude of simultaneous waves less than 50mmHg (P= 0.003) were statistically significant. In conclusion, the transition of diffuse esophageal spasm to achalasia is not frequent at a 2-year follow-up. Dysphagia and simultaneous waves with low amplitude are predictive factors for this degeneration.
机译：某些原发性食管运动障碍发展为门失弛缓症已有记载;但是，这种衰减的真正发生率仍然难以捉摸。这项研究旨在评估：（i）食管弥漫性食管痉挛发展为asia门失弛缓的发生率，以及（ii）这种进展的预测因素。对35名具有弥漫性食管痉挛的测压图像的患者（平均年龄53岁，女性80％）进行了至少1年的随访。排除通过pH监测确认的胃食管反流疾病或可能影响食管运动性的全身性疾病的患者。所有患者均重复食管测压。五名（14％）患者进展为门失弛缓症，平均随访时间为2.1年（1-4年）。人口统计学特征不能预测到门失弛缓，但吞咽困难（P = 0.005）是主要症状，同时波的振幅小于50mmHg（P = 0.003）具有统计学意义。总之，在两年的随访中，食管弥漫性食管痉挛向spa门失弛缓的转变并不常见。吞咽困难和同时出现的低振幅波是这种变性的预测因素。

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