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Metforminuberdosierung mit fatalem Ausgang Insidious Metformin Overdosage with Fatal Outcome

机译:Metforminuberdosierung mit fatalem Ausgang阴险的二甲双胍用药过量,致命

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摘要

We report a case of an elderly woman with diabetes mellitus wich suffered from weakness, lack of appetite and abdominal pain associated with a change of oral antidiabetic medication. Two weeks after the triggering incident the patient was admitted to hospital because of dyspnea, oli-guria and progressive loss of consciousness. Immediately after hospital admission life-threatening organ dysfunctions have been developed caused by a severe lactic acidosis. Inspite of intensive care therapy the patient could not be stabilized. She died of a therapy-refractory circulatory failure. This article describes pathophysiology and symptoms of metformin intoxication. In addition therapeutic options are discussed.
机译:我们报道了一例患有糖尿病的老年妇女,其无力,食欲不振和腹部疼痛与口服抗糖尿病药物的改变有关。触发事件发生两周后,患者因呼吸困难,尿少和意识逐渐丧失而入院。入院后立即出现由严重乳酸性酸中毒引起的危及生命的器官功能障碍。尽管进行了重症监护治疗,患者仍无法稳定下来。她死于治疗难治性循环衰竭。本文介绍了二甲双胍中毒的病理生理和症状。另外,讨论了治疗选择。

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